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• BIOMIMETIC PEPTIDE AND ITS USE AS OSTEOGENIC FACTOR

Spanish Patent ES 2417705 B1

International Patent Application PCT/ES2013/000007

The present invention comprises a peptide with osteogenic capacity, the sequence

of nucleotides codifying for this peptide, as well as a genetic construction contain-

ing said sequence, a vector containing said construction or sequence, and a host
cell containing this vector.

The invention also comprises the use of the peptide, or its pharmaceutical composi-

tions, for bone regeneration or coating of implants and prostheses.

• COMPOUND MATERIAL BY POLYMER AND METALLIC PARTICLES FOR
BIOMEDICAL APPLICATIONS

Spanish Patent ES 2372341 B1

The present invention refers to a material with a polymeric matrix and metallic par-

ticles. It provides a biocompatible and bio-degradable material for the manufacturing

of useful devices for medical applications such as material for bone-synthesis and tis-
sue engineering for the regeneration of bone tissue.

A first aspect of the present invention refers to a material comprising a biodegradable

polymer and metallic particles. A second aspect of the present invention refers to a

procedure for obtaining the biomaterial. A third aspect of the present invention refers
to the use of this biomaterial for the manufacture of an implant or biomedical device

for the repair and regeneration of bone tissue.

• DEVICE AND METHOD FOR INTAKE MONITORING

Spanish Patent ES 2353711 B2

The invention consists in a method of transparent monitoring of the intake, a moni-
toring device and a method to associate overall weight variations to individual

containers. Transparent monitoring is that where the guest has meals in the most

possible similar way to a situation in the absence of monitoring. This is a historical
challenge for intake monitoring.

The present invention proposes a method and a device for the transparent intake

monitoring. A solution for the transparent monitoring of the intake is achieved be-

cause the method can, at any moment, automatically associate the weight varia-
tion, detected by a sole measurement in a containers bearing surface, to the con-

tainer where it was originated.

The invention also comprises a monitoring device specifically designed for this kind
of measurements and association.
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• LIPOPHILIC DERIVATIVES OF NUCLEIC ACIDS
OR
P
Spanish Patent ES2368300B1
RE
L
In this invention, new siRNA derivatives are described, which facilitate siRNA cel- A
NU
lular administration, and are more stable to nucleases, what makes them more N
A
effective for the inhibition of gene expression. These siRNA duplex can be trans- N /
fected into human cells, efficiently entering the cells where they triggers the siRNA B
-B
mechanism, in a similar way to the unmodified ones, including the specific inhibi- R
BE
tion of the gen with the complementary sequence to the siRNA.
CI

Synthesis procedures are described as well. Moreover, another aspect of the inven-
tion is the pharmaceutical compositions containing, at least, an excipient or phar-
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