Page 46 - MemoriaDEM-Eng
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RESEARCH GROUPS
Transgenic Animal Models and Gene Therapy
PROGRAMME: P3
Approaches for Diabetes
Group Members
Lead Researcher
Bosch Tubert, Fàtima
STAFF MEMBERS
Casellas Comallonga, Alba
Contact:
Centro de Biotecnología Animal y Terapia Genética
Edificio H-Campus. Univ. Autónoma de Barcelona
Phone: (+34) 93 581 41 82
E.mail: [email protected] · Website: http://www.uab.cat
Main lines of research
• Study of causes and pathophysiological mechanisms of diabetes and obesity.
- Study of the role of pancreatic ß cell alterations in the development of dia-
betes.
- Identification of novel genes in adipose tissue involved in the development
of diabetes and obesity.
- Identification of novel mechanisms involved in browning of white adipose
tissue.
• Development of new gene therapy approaches for diabetes
- Gene therapy approaches for the treatment of type 1 diabetes centered
on genetic engineering of skeletal muscle to produce insulin and/or increase
glucose uptake.
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20
- Gene therapy approaches for type 2 diabetes and obesity centered on ge- T
R
netic engineering of skeletal muscle and/or the liver.
PO
E
- Study of in vivo pancreas regeneration in diabetic animals: L R
A
Regeneration of endocrine pancreas by IGF-1 NU
N
Betasel: in vivo selection of genes to improve beta cell mass
A
/
- Development of new approaches for type 2 diabetes and obesity centered on EM
genetic engineering of adipose tissue.
D
ER
B
CI
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