Page 55 - MemoriaDEM-Eng

www.ciberdem.org

Most relevant • saMIno s, ReVuelta-CeRVantes j, VInaIXa M, RodRíGuez Ma, ValVeRde aM, CoRReIG X. A (1)H NMR
metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regene-
scientific ration after partial hepatectomy.Biochimie. 2012 Dec 12;.

articles
• Mallol R, RodRíGuez Ma, bRezMes j, Masana l, CoRReIG X. Human serum/plasma lipoprotein analy-
sis by NMR: application to the study of diabetic dyslipidemia.Prog Nucl Magn Reson Spectrosc.

2013 Apr;70:1-24.

• Catalán ú, RodRíGuez Má, Ras MR, MaCIá a, Mallol R, VInaIXa M et al.. Biomarkers of food intake
and metabolite differences between plasma and red blood cell matrices; a human metabolo-
mic profile approach.Mol Biosyst. 2013 Jun;9(6):1411-22.

• bondIa-Pons I, Cañellas n, abete I, RodRíGuez Má, PeRez-CoRnaGo a, naVas-CaRReteRo s et al.. Nutri-
metabolomics: subtle serum metabolic differences in healthy subjects by NMR-based meta-

bolomics after a short-term nutritional intervention with two tomato sauces.OMICS. 2013
Dec;17(12):611-8.

• Canellas n, sola-albeRICh R, bRezMes j, Mallol R, Valls RM, RodRíGuez Ma, VInaIXa M, anGueRa a,
C X. Use of multivariate chemometric algorithms on H-1 NMR data to assess a soluble
oRReIG
fiber (Plantago ovata husk) nutritional interventionCHEMOMETRICS AND INTELLIGENT LABO-
RATORY SYSTEMS. 2013;121:1-8.

COLLABORATIONS WITH GROUPS FROM CIBERDEM á
ñ
Highlights
• Group J. Guinovart: Metabolomic study of neuronal cells under hypoxia ó

• Group R. Gomis: Metabolomic study of adipose tissue of obese animal models
• Group R. Sim: Metabolomic study in cells from the pigment epithelium of the retina in

hyperglycemia and / or hypoxia
• Group L. Ibez: Metabolomic study in PCOS patients undergoing different treatments

• Group L. Masana: Study of diabetic dyslipidemia through advanced characterization of
lipoproteins

• Group A.Novials: Study of the effects of exercise in T1DM

• Group A. Novials: Characterization of pancreatic islets in diabetic rats from images obtai-
ned by mass spectrometry (MALDI-TOF)

• Group J. Egido: Metabolomic study in patients with diabetic nephropathy
• Group G. Rojo: Metabolomics characterization of dairy products to assess their impact on

health in T2DM patients

• Group A. Valverde: Metabolomic study on liver regeneration
• Participation in the project Pilchardus (transversal project CIBERDEM)

RELEVANT PROJECTS:

• SAF2011-30578: Identification of metabolic pathways in neurodegeneration of retina in-
duced by hyperglycemia and ischemia through an approximation of metabolomics and
proteomics

• TEC2012-31074: Development of nanostructured surfaces and metabolic image proces-
sing algorithms for NIMS: application to the study of pancreatic islets in diabetic rats

RELEVANT RESULTS ACHIEVED:

• Creation and validation of an advanced method for lipoprotein characterization
• Identification of biomarkers of subclinical atherosclerosis in PCOS patients
13
20
• Identification of metabolic pathways altered by hyperglycemia and/or hypoxia in cells T
OR
from the pigment epithelium of the retine P
• Creation and validation of a new algorithm for the identification of unknown metabolites RE
L
by mass spectrometry
A
INNOVATION
NU
N
• Registration of two european patents relating to the creation of an advanced method A
for lipoprotein characterization (EP13382478.9) and for modeling of HDL in atherogenic M /
E
dyslipidemia (EP13382477.1) D
• Creation of Biosfer Teslab (http://biosferteslab.com/es/), an spin-off company of the ER
B
University Rovira i Virgili to commercialize an advanced lipoprotein test (Liposcale)
CI

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