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• M M, l-R M, I M, o-o M, e-M hF. Circulating
Most relevant uRRIuqueaMíReznsenseRjedajedasCobaRoRReale
markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic
scientific review and meta-analysisHum Reprod Update. 2013;19(3):268-88.

articles
• MaRtínez-GaRCía Má, Montes-nIeto R, FeRnández-duRán e, InsenseR M, luque-RaMíRez M,
esCobaR-MoRReale hF. Evidence for masculinization of adipokine gene expression in

visceral and subcutaneous adipose tissue of obese women with polycystic ovary
syndrome (PCOS)J Clin Endocrinol Metab. 2013 Feb;98(2):E388–E396 .

• M-n R, I M, M-G Ma, e-M hF. A Nontargeted
ontesIetonsenseRaRtínezaRCíasCobaRoRReale
Proteomic Study of the Influence of Androgen Excess on Human Visceral and Subcu-
taneous Adipose Tissue ProteomesJ Clin Endocrinol Metab. 2013];98(3):E576-E585.

• b s, F-d e, a M, M d, á-b F, l-R M,
oRRueleRnándezuRánlPañésaRtílVaRezlasCouqueaMíRez
esCobaR-MoRReale hF. Global Adiposity and Thickness of Intraperitoneal and Mesente-
ric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome

(PCOS).J Clin Endocrinol Metab. 2013;98(3):1254-1263.

• M. luque-RaMíRez, M. a. MaRtínez-GaRCía, R. Montes-nIeto, e. FeRnández-duRán, M. Insen-

seR, M. alPañés, h. F. esCobaR-MoRReale. Sexual dimorphism in adipose tissue function
as evidenced by circulating adipokine concentrations in the fasting state and after an

oral glucose challengeHuman Reproduction. 2013;28(7):1908–1918.

During 2013 we have studied the influence of sex steroids on the mechanisms
Highlights
implicated in abdominal adiposity and adipose tissue dysfunction. This line of
research has lead to several scientific articles indicating that hyperandrogenic

women have increased global adiposity and visceral fat when compared with con-

trol women. Though to a lesser extent, these women resemble men in their an-
thropometric and metabolic characteristics at the gene expression and protein

abundance levels. We have also confirmed the existence of a sexual dimorphism
in adipose tissue at these levels.

With the funding provided by a FIS grant (Intrasalud PI11/00357) we are carrying

out a study in women with and without androgen excess and men with the aim to

determine the hormonal, metabolic, inflammatory, oxidative stress responses to
the different dietary macronutrients. The study of the polycystic ovary syndrome

suggests that certain macronutrients, particularly soluble carbohydrates, induce

unfavorable inflammatory and oxidative responses that may contribute to its as-
sociation with insulin resistance, abdominal adiposity and cardiovascular risk.

Regarding collaborations, we have published the proteomic study of visceral adi-

pose tissue in overweight patients with type 2 diabetes (Dr. Tinahones’ group,
CIBEROBN), we are currently collaborating with the groups of Drs. Pasquali (Uni-

versity of Bologna, Italy), Kelestimur (University of Erciyes, Turkey) and Pignatelli

(University of Porto, Portugal) and participate in collaborative efforts addressing 13
the study of polycystic ovary syndromeof the European Society of Endocrinology 20
T
and the Androgen Excess & PCOS Society. Regarding clinical practice we have OR
P
contributed to the clinical guideline “Definition and significance of polycystic ovar- RE
ian morphology: a task force report from the Androgen Excess and Polycystic L
A
Ovary Syndrome Society. Hum Reprod Update. Epub 2013 Dec 16. doi: 10.1093/ NU
humupd/dmt061”.
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