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• p N, L JJ, M-B r, M MC, J M, o i. Transcriptional
Most relevant LaNeLLozaNoorauChasaMuNtiMeNorDás
analysis of the intestinal mucosa of patients with ulcerative colitis in remission re-
scientific veals lasting epithelial cell alterations.Gut. 2013 Jul;62(7):967-76.

articles
• paNés J, López-saNroMáN a, BerMeJo F, garCía-sáNChez v, esteve M, torres y. Early azathio-
prine therapy is no more effective than placebo for newly diagnosed Crohn’s disease.

Gastroenterology. 2013 Oct;145(4):766-74.e1.

• CLeyNeN i, goNzáLez Jr, Figueroa C, FraNKe a, MCgoverN D, BortLíK M. Genetic fac-
tors conferring an increased susceptibility to develop Crohn’s disease also in-

fluence disease phenotype: results from the IBDchip European Project.Gut. 2013
Nov;62(11):1556-65.

• J a, D e, r e, t r, g-s v, g Jp. A genome-wide
uLiàoMèNeChiCartortosaarCíaáNChezisBert
association study on a southern European population identifies a new Crohn’s disea-
se susceptibility locus at RBX1-EP300.Gut. 2013 Oct;62(10):1440-5.

•
orDás i, riMoLa J, garCía-BosCh o, roDríguez s, gaLLego M, etChevers MJ. Diagnostic ac-
curacy of magnetic resonance colonography for the evaluation of disease activity and

severity in ulcerative colitis: a prospective study.Gut. 2013 Nov;62(11):1566-72.

The research Group on IBD from Hospital Clínic de Barcelona has provided rele-
Highlights
vant contributions in the area of IBD pathophysiology, and particularly in ulcera-
tive colitis. Using transcriptomic analysis, corroborated by other analytical techni-

ques, we have shown that when achieving endoscopic and histologic remission the

intestinal mucosa does not revert to a healthy condition from a functional point
of view, but shows a potent activation of anti-inflammatory mechanisms, which

may be the basis for the development of new therapies. The group has provided

a relevant contribution to completing the first genome wide association scan in a
Spanish population of ulcerative colitis patients that has identified new suscepti-

bility genes. The group has also made highly relevant contributions in the area of
diagnostics in IBD, particularly in cross-sectional imaging. We have characterized

the value of magnetic resonance imaging for assessment of activity and severity

in ulcerative colitis, and as a continuation of previous work in Crohn’s disease
we have shown the value of magnetic resonance imaging for assessment of the

therapeutic response. The group has also provided significant contributions to

intramural CIBERehd projects lead by other research groups in the area of IBD.

The research capacity of the members of the group is demonstrated also by the
fact that in addition to the group coordinator (JP) two other members of the group

(AS, DB) lead respective national competitive research projects. In addition, the
group has established important contracts for research projects on basic science

with pharmaceutical industries aimed at determining mechanisms of action, proof

of concept and identification of new therapeutic targets.
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