Page 116 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
Liver Cancer and Cancer of G0063

the Digestive System

Group Members
Lead Researcher

Pastor Anglada, Marçal
STAFF MEMBERS
íIglesias Garanto, Ingrid

Prez Torras, Sandra
Contact:
í
ASSOCIATED MEMBERS
Dep de Bioqumica y Biología Molecular.
Facultad de Biologa. Universidad de Barcelona. Casado Merediz, Fco Javier
Mazo Snchez, Adela
C/ Diagonal, 643. Barcelona · Phone: (+34) 93 402 15 43
E.mail: [email protected]

Main lines of research

• Analysis of the cellular transportome and its role on oncogenesis in liver and
gastrointestinal tumors.

We will dissect the interactome of membrane proteins whose expression is
known to be altered in tumors. This project combines the “transceptor” con-

cept with the analysis of the protein networks incorporating these membrane
proteins. We anticipate that these networks are relevant to oncogenesis.

• Molecular pharmacology and pharmacogenetics of drug transporters.

We will study drug-transporter interactions and the impact of genetic variability
on transporter functionl. The ultimate goal is to understand how transporter

expression patterns determine drug responsiveness.
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• Generation of preclinical models to study newly developed anticancer drugs. T
R
- Genetic engineering of cellular models for the preclinical assay of drug bioa-
PO
vailability.
E
L R
Based upon the increasing interest of the pharmaceutical companies and regu- A
NU
latory agencies to establish preclinical assays of drug-transporter interaction, N
we are developing epithelial barrier models to anticipate pharmacokinetics in- A
teractions among drugs.
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HD
- New animal models for the study of new drugs against pancreatic adenocar- E
ER
cinoma.
IB
C
The MPET laboratory has a platform of orthotopic models derived from human
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pancreatic adenocarcinomas, suitable for the preclinical assessment of novel

antitumor therapies.