Page 122 - MemoriaEHD-Eng

RESEARCH GROUPS
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PROGRAMME:
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G0006
Liver Cancer and Cancer of
the Digestive System

Group Members
Lead Researcher

Prieto Valtueña, Jesús Ma
STAFF MEMBERS
Barbero Lpez, Roberto

Celay Leoz, Ion
Contact:
D’avola, Delia

Clnica Universitaria de Navarra. Larequi Ardanaz, Eduardo
Website: www.cun.es
Reboredo Prol, Mercedes
Santa Mara Monasterio, Eva

Uriarte Daz-Varela, Iker
Main lines of research

ASSOCIATED MEMBERS
Civeira Murillo, Ma Pilar • Study of the cellular and molecular mechanisms of liver response to acute and

Herrero Santos, Jos Ignacio chronic injury, and hepatocarcinogenesis .

Iarrairaegui Bastarrica, Mercedes • Design of hepatoprotective strategies against situations of injury/acute liv-
Quiroga Vila, Jorge Augusto
er failure and identification of therapeutic targets to slow the progression of
Sangro Gmez-Acebo, Bruno Carlos
chronic liver disease and its malignant transformation.

• Development of hepatoprotective therapies including insulin-like growth factor

type 1 (IGF1) and cell therapy with endothelial cell progenitors.

• Characterization of the effects of amino-terminal protein modifications and 13
their implications for the development of hepatocellular carcinoma and liver 20
T
regeneration, and development of inhibitors of these enzymes as novel anti- R
tumor molecules.
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• Clinical development of new agents with specific therapeutic targets. L R
A
• Immunotherapy with immunological checkpoint inhibitors and universal and
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personalized peptide vaccines.
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• Improved procedures and materials for intra-arterial therapy of liver tumors: HD
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radioembolization and chemoembolization .
ER
IB
• Improvement of the procedures and results of the surgical treatment of liver C
cancer including liver transplantation and surgical resection in patients with
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and without cirrhosis