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• r L, a v, M a, C p. Natural capsaicinoids improve swallow response
Most relevant oFesrreoLaartíNLavé
in older patients with oropharyngeal dysphagia.Gut. 2013 Sep;62(9):1280-7.
scientific
• ryChter J, CLavé p. Intestinal inflammation in postoperative ileus: pathogenesis and
articles
therapeutic targets.Gut. 2013 Nov;62(11):1534-5.

• aLMiraLL J, roFes L, serra-prat M, iCart r, paLoMera e, arreoLa v. Oropharyngeal dyspha-
gia is a risk factor for community-acquired pneumonia in the elderly.Eur Respir J.

2013 Apr;41(4):923-8.

• giL v, parsoNs s, gaLLego D, huiziNga J, JiMeNez M. Effects of hydrogen sulphide on mo-
tility patterns in the rat colon.Br J Pharmacol. 2013 May;169(1):34-50.

• F-B Ja, h MD, M v, v p. PAR-2-mediated control
erNáNDezLaNCooLLeNBergartíNezergara
of barrier function and motility differs between early and late phases of postinfec-
tious gut dysfunction in the rat.Am J Physiol Gastrointest Liver Physiol. 2013 Feb

15;304(4):G390-400.

In 2013 we described two new pharmacological targets (TRPV1/TRPA1) with the-
Highlights
rapeutic effects on the oropharyngeal motor response. We designed and carried
out two large clinical trials with positive results and application to clinical prac-

tice of sensory transcutaneous and intrapharyngeal electrostimulation methods

to treat post-stroke dysphagia. We characterized the pharyngeal cortical sensory
evoked potential and showed that patients with dysphagia present impairments

in both the motor and sensory pathways, and we established the relation bet-
ween oral microbiota, oropharyngeal aspirations and aspiration pneumonia in ol-

der patients and assessed the serious risk factor that dysphagia and malnutrition

represent for these patients. In this area we hold an international patent PCT/
EP2005/04252 and have participated in a European project (OPVK), and an in-

ternational guideline (Terminology and Definitions for Texture-modified foods and

thickened liquids used in dysphagia) and in the creation of a European scientific
association (European Society for Swallowing Disorders). We have contributed to

the description of the impairments to the permeability of the esophageal sphincter
in gastroesophageal reflux disease, the mechanisms of control of peristalsis and

disorders in gastric and gallbladder motility and release of postprandial gastroin-

testinal peptides in anorexia of frail aging patients. We have started studies on the
clinical relevance of nutritional, anabolic and inflammatory disorders and the role

of ghrelin in sarcopenia and frailty. We have characterized the role of mast cells

in postoperative ileus following colorectal surgery in humans. The main results of
the basic research were the description of the effect of PAR-2 receptors on the

epithelial barrier and the role of intestinalmicrobiota in the expression of sensory
innervation, new neurotransmitters (H2S) in animal models and the consolidation

of the study of motility in vitro with human gastro-intestinal samples through
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mechanical, electrophysiological, immunohistological and molecular techniques.
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