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• a N, g-s LJ, a F, F ha, v vM, B MD. ER
Most relevant postoLovaoMezuCerQuiaLegreuNesiCtorarraChiNa
stress in human hepatic cells treated with Efavirenz: mitochondria again.J Hepatol.
scientific 2013 Oct;59(4):780-9.

articles
• ortiz-Masiá D, CosíN-roger J, CaLatayuD s, herNáNDez C, aLós r, hiNoJosa J. Hypoxic
macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD.

Mucosal Immunol. 2013 Dec 4;.

• De paBLo C, orDeN s, peris Je, BarraChiNa MD, espLugues Jv, aLvarez a. Profile of leukocyte-
endothelial cell interactions induced in venules and arterioles by nucleoside reverse-

transcriptase inhibitors in vivo.J Infect Dis. 2013 Nov 1;208(9):1448-53.

• CosíN-roger J, ortiz-Masiá D, CaLatayuD s, herNáNDez C, aLvarez a, hiNoJosa J. M2
macrophages activate WNT signaling pathway in epithelial cells: relevance in

ulcerative colitis.PLoS One. 2013;8(10):e78128.

• herNáNDez-MiJares a, roCha M, rovira-LLopis s, BañuLs C, BeLLoD L, De paBLo C. Human
leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2

diabetic patients and their association with silent myocardial ischemia.Diabetes

Care. 2013 Jun;36(6):1695-702.

In the last year we have demonstrated the relevance of the innate immune sys-
Highlights
tem, in particular macrophages, in mechanisms of mucosal regeneration in inflam-
matory bowel disease (IBD). These cells function as a source of Wnt and Notch

ligands, molecules that mediate mechanisms of epithelial regeneration. In addi-

tion, this expression seems to be associated with the macrophagic phenotype. Our
results point to the pharmacological potential of modulating the macrophagic phe-

notype to aid mucosal recovery, one of the main objectives of current IBD therapy.

The results we have obtained about the role of the antiretroviral drug Abacavir in
the genesis of inflammation, despite not yet having been published as an article,

have generated considerable controversy and have led to a series of invitations to

present our data in national and international meetings.

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