Page 82 - MemoriaEHD-Eng

RESEARCH GROUPS

ñ
ííí

í
í

ñ

PROGRAMME:
G0035
Cholestasis and Metabolic
Disorders
ó

Group Members
Lead Researcher

Fdez.-Checa Torres, José C.
STAFF MEMBERS
Matias Hernando, Nuria

Nuez Pozuelo, Susana
Contact:
ASSOCIATED MEMBERS
Instituto de Investigaciones Biomédicas.
C/ Rossell, 161, 6a Planta. Barcelona.
Caballera Rovira, Juan
Colell Riera, Anna

Garca-Ruiz, Ma Carmen
Llus Duquez, Josep M Main lines of research

Mar Garca, Montserrat
Morales Muoz, Albert
• Functional relationship between methionine metabolites, acid sphingomye-

linase and phosphatidylcholine in steatohepatitis.

• Development of non-invasive diagnostic methods for diagnosis and prog-
nosis in alcohol-induced liver disease.

• Ischemia-reperfusion hepatocellular damage mechanisms and their regu-

lation based on antioxidant and antiinflammatory strategies.

• Sphingolipid and mitochondrial oxidative-stress regulation of cell death. 13
• Contribution of sphingolipids and autophagy to lipid metabolism and non-
20
T
alcoholic steatohepatitis.
R
PO
• Regulation of cholesterol homeostasis in patients and experimental models E
of non-alcoholic steatohepatitis and ischemia-reperfusion injury.
L R
A
• Mechanisms responsible for cholesterol transport to the mitochondria.
NU
N
• Role of cholesterol in hepatocellular carcinoma response to chemotherapy
A
/
• Parenchyma-stroma interaction in cancer and ischemia/reperfusion-indu- HD
E
ced liver damage: lipid therapies.
ER
• Role of cholesterol and the mitochondria in disease.
IB
C
• Contribution of TNF receptors and cathepsins to fibrosis and inflammation
82
of the liver.