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• s-c M, c rJ, c F, F F, P-l a, G e. Metabolo-
Most relevant anzortesarbaJorisPiiGuerasinedaucenaratacos
mic profile of umbilical cord blood plasma from early and late intrauterine growth
scientific restricted (IUGR) neonates with and without signs of brain vasodilation. PLoS One

articles
2013;8:e80121.

• Muñoz-Moreno e, arbat-Plana a, batalle d, soria G, illa M, Prats-Galino a, et al. A mag-

netic resonance image based atlas of the rabbit brain for automatic parcellation.
PLoS One 2013;8:e67418.

• i M, e e, b d, a-P a, M-M e, F F, . Long-term
llaiXarchatallerbatlanauñozorenoiGueraset al
functional outcomes and correlation with regional brain connectivity by MRI diffusion
tractography metrics in a near-term rabbit model of intrauterine growth restriction.

PLoS One 2013;8:e76453.

• Valenzuela-alcaraz b, crisPi F, biJnens b, cruz-leMini M, creus M, sitGes M, et al. Assisted
reproductive technologies are associated with cardiovascular remodeling in utero

that persists postnatally. Circulation 2013;128:1442–50.

• batalle d, Muñoz-Moreno e, FiGueras F, barGalló n, eiXarch e, Gratacos e. Normali-

zation of similarity-based individual brain networks from gray matter MRI and its
association with neurodevelopment in infants with intrauterine growth restriction.

Neuroimage 2013;83:901–11.

Highlights
The unit 719 consists of a clinical and basic research team. It is one of the few
groups in Spain specialized in fetal medicine. Among our main areas of research,

we are focus on fetal diseases and pregnancy conditions classified as rare disea-
ses, such as fetal malformations, preeclampsia or acute respiratory distress of the

newborn. The research aims to (1) understand pathophysiological mechanisms

and fetal programming, (2) develop biochemical and imaging biomarkers, (3)
develop new therapies. The group is interdisciplinary and has clinicians, biologists

and bioengineers.

Some of our major scientific and translational milestones achieved in 2013 inclu-

de:
• Characterization of the effects of fetal growth restriction and congenital heart

diseases using imaging biomarkers (Neuroimage 2013, PLoS One 2013).

• In fetal cardiology, development of methods for the study of fetal cardiac

function, and characterization of the impact of different diseases on the fetal

cardiac function. For the first time, we have shown that assisted reproduction
is associated with cardiovascular programming in children (Circulation 2013)

• Consolidation of the first monographic fetal neurology unit, applying new bio-

markers and screening protocols in fetal CNS.

• Establishment of the first fetal cardiac function unit in Spain, with distinct algo-
13
rithms for predicting prognosis in congenital heart disease.
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• Development of a new method of quantitative image analysis, in collaboration OR
with our spin-off Transmural Biotech, for predicting the risk of neonatal respi- P
RE
ratory distress. The patent application has been filed in late September 2013.
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A
• Coordination of the FetalMed-PhD Project: the First Joint Doctorate in Fetal Me- NU
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dicine funded by the European Community - Erasmus Mundus Joint Doctorate. A
Total funding of € 5.92 million. Start Date: 2013.
R /
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