Page 134 - MemoriaER-Eng

RESEARCH GROUPS

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PROGRAMME:
Group U734

Genetic Medicine
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Group Members
Lead Researcher
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STAFF MEMBERS
Gonzlez Manchón, Consuelo
Alquzar Burillo, Carolina

Horrillo Ledesma, Anglica
Contact:
ASSOCIATED MEMBERS
CIB, CSIC, Dep. de Medicina Celular y Molecular
C/ Ramiro de Maztu, 9. 28040 Madrid. Fontela Casado, Toms
Garca Arias-Salgado, Elena
Phone: (+34) 91 837 31 12 · E.mail:[email protected]
Website: https://www.cib.csic.es/es/grupo.php?idgrupo=58”
Martn Requero, ngeles
Snchez Ayuso, Matilde
https://www.cib.csic.es/es/grupo.php?idgrupo=57

Main lines of research

• X-linked hyper IgM syndrome animal model generation. Preparation of

mice with CD40L-/- platelets and/or vascular endothelial cells and com-

parative analysis with complete CD40L-/- mice.

• Molecular basis of platelet hyperreactivity associated to thrombotic pro-
cesses.
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• Use of lymphoblastic cell lines from Amytrophic Lateral Sclerosis (ALS), 20
T
frontotemporal dementia (associated to progranuline mutations) and Alz- R
PO
heimer patients for a systematic study of mechanisms of cell death and E
survival in neurodegeneration.
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• Molecular basis of hemorrhagic syndromes (Glanzmann thromboasthenia, NU
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Bernard-Soulier syndrome, FXIII deficiency).
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• Function of the GPIb-IX complex in thrombin-induced platelet activation.
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• Production of animal models with conditional ablation of the podocalyxin B
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gene in several tissues.

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