Page 168 - MemoriaER-Eng
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RESEARCH GROUPS
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PROGRAMME:
Group U752
Inherited Metabolic
Medicine
Group Members
Lead Researcher
Giraldo Castellano, Pilar
STAFF MEMBERS
Alfonso Palacn, Mara Pilar
éóIrun Irun, Mara Pilar
Contact:
ASSOCIATED MEMBERS
Instituto Aragons de Ciencias de la Salud (IACS)
Unidad de Investigación Traslacional. Capablo Liesa, Jos Luis
Latre Martnez, Paz
Hospital Universitario Miguel Servet.
Po Isabel La Catlica 1-3. Zaragoza.
Pocov Mieras, Miguel
Roca Espiau, Mercedes
E.mail: [email protected] · Website: www.feeteg.org
Senz de Cabezn, Alicia
Main lines of research
• Gaucher disease epidemiology, in Spain: National Registry acredited by ISO
9001 (Num EC2751/07).
• Genetic analysis and search of genes related to clinical heterogeneity. Directed
mutagenesis. DNA, serum, plasma and leukocyte patient samples biobank.
• Study of biomarkers and inflammatory cytokines and its relationship with re-
sponse to treatment.
• Study of bone disease by imaging techniques and its relationship with plasma
biomarkers.
• Neurological disease evaluation by clinical, neurophysiological and imaging 13
methods.
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• Clinical research of new drugs on clinical trials (OGT-011, TKT034, TKT039, R
Protalix). Independent clinical trial.
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• Epidemiology of hematological neoplasias. Gene expression marker study and L R
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search of polymorphisms accounting for familial aggregations.
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• Approach to study of internalization of nanoparticles containing small drug mol- N
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ecules on monocytes and macrophages and application to treat deposit dis- /
eases.
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• Analysis of the effect of pharmacological chaperones on protein mutants in B
Gaucher Disease.
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• Plasma miRNAs profile in Haematological malignancies and predictor use to
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developed acute leukaemia.