Page 87 - MemoriaER-Eng

www.ciberer.es

• b l., M-F, r b P. (2013) The logic of Gene Regulatory
Most relevant eccariarcoerreresand oVolenta
Networks in early vertebrate forebrain patterning. Mech. Dev. 130, 95-111. (cover
scientific caption article).

articles
• indrieri, a., conte, i., chesi, Gc, quartararo, J., cerMola M, tate, r., Ghezzi, d., zeVia-
ni M, GoFFrini, P., Ferrero, i., boVolenta, P., and Franco, b. (2013) The impairment of

HCCS leads to MLS syndrome by activating a non-canonical cell death pathway in
the brain and eyes. EMBO Mol Med. 5, 280–293. (cover caption article).

• F a., F r.*, b l*, b J., t V., V c., n-l, F.,
erriaVaroeccariertoliniosettierzeroliietoóPez
Mercurio s., la reGina, F., ottolenGhi s., boVolenta P. and nicolis, s.k. (2013) Sox2 is
required for embryonic development of the ventral telencephalon through the acti-

vation of the ventral determinants Nkx2.1 and Shh. Development 140, 1250-1261.
*Equally contributing.

• c i. b s b P. (2013) Noncoding RNAs in the development of sen-
onteanFiand oVolenta
sory organs and related diseases. Cell. Mol. Life Sci. 70:4141–415.

• sanchez-arrones, l.*, nieto-lóPez, F.*, sanchez-caMacho, c., carreres M.i., herrera, e.,

okada, a. and boVolenta, P. (2013) Shh/Boc signaling is required for sustained gene-
ration of ipsilateral-projecting ganglion cells in the mouse retina. J. Neurosci. 33,

8596-8607. (Featured article). *Equally contributing.

During this year the team has progressed significantly in elucidating the molecu-
Highlights
lar mechanisms underlying known congenital eye diseases as well as towards the
identification of the gene regulatory networks underlying eye development in ver-

tebrates, a consolidated approach that is continuously leading to the identification

of additional candidates gene for microphthalmia, anopthalmia and coloboma.
The work of the team was supported by national and international grants and

was presented in eight international congresses with a total of ten communica-

tions. The most relevant are invited presentations at the following conferences:
1) Signaling in vertebrate hedgehog and Gli signaling in stem cells and cancer. ó

Fondation des Treilles, France 15-20 April. 2) British Society for Developmental

Biology (BSDB). Axon guidance and Regeneration. 28-30 August. Aberdeen Uni-
versity, Scotland, UK. 3) International Mammalian Genome Society. September

16-18.Salamanca(pleanaryconference). 4)2ndMeetingPortugueseSocietyfor
DevelopmentalBiology(SPBD)24-26October. Theteamwasalsoinvolvedinthe

organization of the very successful 8th European Zebrafish meeting in Barcelona.

Different members of the unit has been involved in teaching and outreach acti-

vities, including the delivery of seminars in national and international research
centres, the participation in the Developmental Neurobiology Course of the Mas-

ter in Neuroscience UAM-Instituto Cajal; the Development course of the Master

in Molecular Biology of the UAM and the 2nd International course “From Pigment 13
Cell Development to Melanomas” Institut Curie/CNRS. Marco Cardozo has suc- 20
T
cessfully (Magna Cum Laude) defended his doctoral thesis titled “The Shh binding OR
protein Cdon is required for patterning and morphogenesis of the vertebrate eye”. P
RE
Facultad de Ciencias, Universidad Autnoma de Madrid.
L
A
NU
N
A
R /
E
ER
B
CI

87