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• r c, c c, P l, c-n JM, g c, S e. Critical role of
Most relevant iuSoMPAnYiQuerASerdáicoláSonZáleZerVerA
fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the
scientific arterial endothelium.Thorax. 2013 Feb;68(2):177-86.

articles
• AlMudéVer P, MilArA J, de diego A, SerrAno-MollAr A, XAuBet A, PéreZ-ViZcAino F. Role of
tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary

fibrosis.Thorax. 2013 Oct;68(10):938-48.

• MilArA J, Peiró t, SerrAno A, cortiJo J. Epithelial to mesenchymal transition is in-
creased in patients with COPD and induced by cigarette smoke.Thorax. 2013

May;68(5):410-20.

• MilArA J, Peiró t, SerrAno A, cortiJo J. Authors’ response to: epithelial mesenchymal
transition (EMT) in small airways of COPD patient.Thorax. 2013 Aug;68(8):784.

• M J, S A, P t, A e, g A, M M. Aclidinium inhibits ciga-
ilArAerrAnoeirórtigueSAVAldàirAlPeiX
rette smoke-induced lung fibroblast-to-myofibroblast transition.Eur Respir J. 2013
Jun;41(6):1264-74.

Highlights
RELEVANT PUBLIC PROJECTS

• Cigarette smoke-induced remodeling and COPD in human and animal models:
pharmacological modulation CP11/00293. (MIGUEL SERVET ISCIII)

• Pharmacological modification of cigarette smoke-induced COPD and remode-

ling: insights in human and animal models (SAF2011- 26443)

• Nuevas dianas farmacológicas para el tratamiento de la EPOC y sus comorbili-

dades vasculares. (Ayudas programa Prometeo para grupos de investigación
de excelencia-prometeo/2013-fase II/ Generalitat Valenciana)

RELEVANT PRIVATE PROJECTS

• Effects of phosphodiesterase 5 system in pulmonary hypertension-associated
pulmonary idiopathic fibrosis: an in vitro study (PFIZER)

•
Effects of Roflumilast N-oxide, a PDE4 inhibitor on selected functions of polari-
zed human bronchial epithelial cells in presence or absence of a long acting ß2-

agonist (LABA), a long acting muscarinic antagonist (LAMA), a glucocorticoid, a
PDE5 inhibitor or a statin (NYCOMED Pharma S.A)

•
Anti-inflammatory activity of long-acting muscarinic receptor antagonists
(LAMA) in those situations of corticoid-resistance on in vitro models relevant to

COPD. (ALMIRALL PRODESFARMA S.A.)

• Characterization of differential effects of roflumilast N-oxide versus corticoste-

roids and long-acting ß2-adrenergic agonist (LABA) on neutrophils from healthy
and COPD patients: Mechanistic studies. (FOREST RESEARCH INSTITUTE)

•
Analysis of the additive/synergistic anti-inflammatory effects of combinations 13
20
of aclidinium bromide, corticosteroids and long-acting ß2-adrenergic agonist T
OR
(LABA) on neutrophils from healthy and COPD patients. (ALMIRALL PRODES- P
FARMA S.A)
RE
L
•
Analysis of the additive/synergistic anti-inflammatory effects of combinations A
NU
of MABA and corticosteroids on neutrophils from healthy and COPD patients. N
A
(ALMIRALL PRODESFARMA S.A.)
S /
E
ER
B
CI

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