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• c-r F, M-g MA, M M, d-c J, P M l, M-
Most relevant AMPoSodrígueZArtíneZArcíAArtíneZurAnAntollAeñAdeAS
deu MJ. Association between obstructive sleep apnea and cancer incidence in a large
scientific multicenter Spanish cohort.Am J Respir Crit Care Med. 2013 Jan 1;187(1):99-105.

articles
•
FrAnQueSA M, HoogduiJn MJ, reinderS Me, eggenHoFer e, engelA Au, MenSAH Fk. Mesen-
chymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons

learned from first clinical trials.Transplantation. 2013 Aug 15;96(3):234-8.

• kiM JH, SerrA-PicAMAl X, tAMBe dt, ZHou eH, PArk cY, SAdAti M. Propulsion and naviga-
tion within the advancing monolayer sheet.Nat Mater. 2013 Sep;12(9):856-63.

• l t, M e, g e, c J, n J, F r. Local micromechanical pro-
uQueeloArretAortiellAicHolSArré
perties of decellularized lung scaffolds measured with atomic force microscopy.Acta
Biomater. 2013 Jun;9(6):6852-9.

• l B g, r ot, M Jd, g V, l n, i V. An in vitro study to assess
iASSiAnZAniArtiiuntAuQueSettA
determinant features associated with fluid sealing in the design of endotracheal tube
cuffs and exerted tracheal pressures.Crit Care Med. 2013 Feb;41(2):518-26.

The group belongs to the CIBER of Respiratory Diseases and is an associated
Highlights
group of CIBER of Bioengineering, Biomaterials, and Nanomedicine. In CiberES

our research is currently focused on the Corporate Programs on Acute Lung Injury
Program (ALI) and Sleep Apnea - Hypopnea Syndrome (SAHS). In CiberBBN we

participate in the project Multimodal Diagnosis by Signal Interpretation of the Res-

piratory System oriented to Pulmonary Diseases and Sleep Disorders (MUDIRES-
2PSD). Our research is interdisciplinary and is developed in collaboration with

other groups of the CIBER. We transfer technology by means of contracts with

companies of respiratory medical devices.
In SAHS program our group is active in the study of the pathophysiology and con-

sequences of the disease. Members of the group have led two publications in 2013

based on a mouse model of melanoma and intermittent hypoxia, showing for the
first time that intermittent hypoxia similar to OSA increases tumor growth - proba-

bly via overexpression of vascular endothelial growth factor – and promotes tumor

metastasis to the lung. We have also published two studies in patients revealing a
significant incidence/mortality of cancer in patients with SAHS. The group leads a

Work Package of the European project CHROMED on home monitoring in patients
with chronic respiratory diseases. We have also developed a platform for telemat-

ics control of CPAP treatment in patients with sleep apnea at home.

Within the ALI program and in order to understand the mechanisms that govern

the cell-matrix interplay in lung repair/regeneration we have characterized the
mechanical properties of the lung extracellular matrix by means of nanotechnolo-

gies. This work has revealed for the first time the mechanical heterogeneity of the

cell niche in different lung structures. In addition, we have evaluated the effect of 13
different decellularization procedures on the nanomechanics of lung matrix. More- 20
T
over, the mechanical forces governing collective migration involved in the tissue OR
repair mechanisms have been identified. We have also developed a lab-on-a-chip P
RE
device to study the cellular response to cyclic deformation.
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