Page 143 - MemoriaES-Eng

www.ciberes.org

the use of Magnetic Resonance Spectroscopy and Mass Spectrometry and differ-

ent statistical tools developed within the group. Our research projects range from

technical developments and chemistry advances to in vitro studies and tracking
biological processes in vivo.

Most relevant • VidorretA M, WAng Z, rodrígueZ i, PAStor MA, detre JA, FernándeZ-SeArA MA. Compari-
son of 2D and 3D single-shot ASL perfusion fMRI sequences.Neuroimage. 2012 Nov
scientific
7;66C:662-671.
articles
• FerrArini A, ruPéreZ FJ, erAZo M, MArtíneZ MP, VillAr-álVAreZ F, PeceS-BArBA g et Al.. Fin-
gerprinting-based metabolomic approach with LC-MS to sleep apnea and hypopnea

syndrome: a pilot study.Electrophoresis. 2013 Oct;34(19):2873-81.

• SerrAno-ruiZ d, lAurenti M, ruiZ-cABello J, lóPeZ-cABArcoS e, ruBio-retAMA J. Hybrid mi- é
croparticles for drug delivery and magnetic resonance imaging.J Biomed Mater Res

B Appl Biomater. 2013 May;101(4):498-505.

• ruiZ A, SAlAS g, cAlero M, HernándeZ Y, VillAnueVA A, HerrAnZ F et Al.. Short-chain PEG

molecules strongly bound to magnetic nanoparticle for MRI long circulating agents.
Acta Biomater. 2013 May;9(5):6421-30.

• PreZ-MedinA c, PAtel n, roBSon M, lYtHgoe MF, ArStAd e. Synthesis and evaluation of

a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated
sodium channels.Bioorg Med Chem Lett. 2013 Sep 15;23(18):5170-3.
ó

The group has recently started a new path in the Spanish National Center for
Highlights
Cardiovascular Research (CNIC). We have just finished installing a smoke expo-

sure chamber used for activities referred to the COPD PCI with mouse models.
We have also commenced a collaborative study with Drs Peces Barba, Agustí and

Cossio aimed to find early markers of COPD and its association with cardiovas-
cular disease, for which purpose we will obtain image and omics data from the

PESA-CNIC- Banco Santander study. For the ALI PCI, we have collaborated with

the group of Dr. Esteban in metabolomic studies and with the group of Dr. Blanch
in the brain-lung association of ALI pig model. An acquisition method for perfusion

MRI has been scheduled for clinical team (see publication in Neuroimage). Several

publications and thesis / dissertations will be obtained from both CIPs that have
been funded by different projects, including the Pulmonary Imaging Network, of

which we are coordinators, funded by the Seventh Framework Program. This work

has enabled a better understanding of the relationship between the composition
and the behavior and interaction of nanoparticles and plasma proteins . Addi-

tional funding has also been achieved in other competitive calls; an ITN within
the same framework program (Cardionext) in which Jesus Ruiz -Cabello is one of
13
the PI, and “La Marat” project in which we are partners. These projects allow us 20
T
to advance in the application of molecular imaging techniques. Finally, in March OR
2013 our group organized an international course entitled “Translational Aspects P
RE
of Cardiovascular and Pulmonary Imaging” involving pharmaceutical companies L
A
(AstraZeneca , Novartis, Boehringer Ingelheim) and representatives of hospitals NU
and public research organizations from different countries. The course was a great N
A
succes allowing to reflect the role of imaging in the translational research chain.
S /
E
ER
B
CI

143