Page 31 - MemoriaES-Eng

www.ciberes.org

The Programme has successfully created a tumor tissue biobank containing tumor
Main results
tissues from patients included in the International Association for the Study of Lung
in 2013
Cancer (IASLC) Cohort and in follow-up until 2016. It has over 250 samples availa-

ble for the analysis of biological markers with potential prognostic capacity. Baseli-

ne clinical information of the patients included in this Cohort living in this territory
was published by CIBERES investigators participating in the Programme (Sanchez

de Cos J. Arch Bronconeumol [Barc] 2013) in 2013. In the line for identifying gene-
tic, epigenetic and proteomic markers with potential prognostic capacity in early-

stage lung cancer patients, CIBERES investigators participating in the Programme

have validated, in biological samples from patients with risk factors for lung cancer
and from patients suffering this disease, originating from clinical series, oxidative

stress marker levels in bronchial secretions and peripheral blood using ELISA and

immunoblotting.

Carbonylation, MDA protein adducts, antioxidants, TNF-α, interferon-γ, TGF-β
and VEGF levels in bronchial secretions, and superoxide, damaged DNA, TNF-α,
á
interferon-γ, TGF-β, VEGF and neutrophil levels in the blood were high in lung can- ó
cer patients. This justifies studying their prognostic significance in the disease (Ba-

rreiro E. Free Radical Biology and Medicine 2013). Investigators participating in the

Programme have also examined the peripheral immune response in patients at risk
of lung cancer due to smoking and COPD, focusing their attention on L-arginine ca-

tabolism and observing that circulating myeloid-derived suppressor cells (MDSCs)

are activated in smokers and remain activated once the person stops smoking in
COPD patients. This analysis has concluded that smoking modulates circulating

MDSCs and that this alteration persists in COPD patients who quit smoking. It has í
allowed observing an effect of exposure to tobacco with potential clinical significan- í

ce (Schrimini Resp Med 2013). As regards epigenetics, it has been observed that

p16 methylation, which is observed in samples obtained non-invasively from me-
diastinal nodes, is a predictor of advanced diseases and therefore has prognostic ñ

value, with the advantage of being able to be examined in non-surgical samples

(Millares, European Respiratory Society Congress).
é

ú
Publications:

• B e, F c, M-J M, S-F A, P l, g J,
ArreiroerMoSelleAteuiMneZáncHeZontiJuAneA
curull V, Oxidative stress and inflammation in the normal air way sand blood
í
of patients with lung cancer and COPD Free Radical Biology and Medicine
65(2013) 859–871.
á

• S S, P J, A A, S J, c B, t J, n B, c
criMinionSguStoriAnooSioorrecillAúñeZórdoVA
r, igleSiAS A, JAHn A, creSPi c, SAuledA J Diferenteial effects of smoking and
í13
COPD upon circulating myeloid derived suppressor cells Respiratory Medicine 20
– Diciembre de 2013 (Vol. 107, Nmero 12, Pginas 1895-1903, DOI: T
OR
10.1016/j.rmed.2013.08.002).
áP
RE
• J. SncHeZ de coS eScun et Al Registro del Grupo Cooperativo de Cáncer de L
A
Pulmn-II de la Sociedad Espaola de Neumologa y Ciruga Torcica. Estudio NU
descriptivo Arch Bronconeumol. 2013;49(11):462–467.
N
A
S /
E
ER
B
CI

31