Page 29 - MemoriaOBN-Eng

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P6. Physiopathology of Body Weight Homeostasis

As a continuation of its work from the previous two-year period, this programme
Description
seeks to implement multidisciplinary studies in various preclinical and clinical mod-
els of energy homeostasis disorder as a basis for generating physiological knowl-

edge (about the mechanisms of energy balance control and related body functions)
and pathological knowledge (relating to disorders in overweight conditions) that

can be translated into clinical practice for treating obesity and its associated co-

morbidities.

The activities will allow implementing studies that aims at identifying new eti-
opathogenic mechanisms and therapeutic targets with traslational potential in

the field of obesity and its complications, essentially by means of studying pre-

clinical models.

It should be pointed out that the nutritional and pharmacological armamentarium
available for treating obesity is very scarce, and at present could be classified as

preoccupying. The potential of different inter- and intracellular signaling systems
determining energy homeostasis will be investigated and studied as a therapeutic

target against obesity. For this purpose, a strategy that contemplates the identifi-

cation of new signals involved in controlling intake and energy expenditure, acting
both on a central level and on particularly relevant peripheral tissues on a metabolic

level, such as the liver, muscle and adipose tissues.

In turn, emphasis is placed on establishing by means of pre-clinical experimental

models, the interactions of the mechanisms of control of body weight and their
dysfunction with determining biological factors (gender, reproductive processes).

The identification of new agonists/antagonists of different adipokines and/or hor-

monal signals affecting body weight homeostasis, inflammation, lipid metabolism
or cardiovascular and hepatic disorders associated with obesity can lead to a real

improvement in the health prospects of obese patients.
13
0
2
RT
PO
General To establish the biological factors and the intra- and intercellular signaling that E
controls body weight homeostasis, as well as disorders in these processes R
Objective
AL
occurring in obesity.
U
NN
A
/
BN
O
ER
B
CI

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