Page 47 - MemoriaOBN-Eng

www.ciberobn.es

Most relevant • Fuente-Martín e, García-cáceres c, Díaz F, arGente-arizón P, GranaDo M, Barrios V et
al.. Hypothalamic inflammation without astrogliosis in response to high sucrose
scientific
intake is modulated by neonatal nutrition in male rats.Endocrinology. 2013
articles
Jul;154(7):2318-30.

• c Ja, a J, h tl. Uncovering novel roles of nonneuronal cells in body
howenrGenteorVath
weight homeostasis and obesity.Endocrinology. 2013 Sep;154(9):3001-7.

• Martos-Moreno Gá, Barrios V, chowen Ja, arGente J. Adipokines in childhood obesity.
Vitam Horm. 2013;91:107-42.

• G M, F n, M l, F Jc, c-t G, a s ..
ranaDoernánDezonGeiGuerasarreñoarraGonaMoret al
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role

of Angiotensin receptors.PLoS One. 2013;8(2):e54984.

• Perianes-cachero a, BurGos-raMos e, PueBla-JiMénez l, canelles s, FraGo lM, herVás-
aGuilar a et al.. Acute up-regulation of the rat brain somatostatin receptor-effector

system by leptin is related to activation of insulin signaling and may counteract
central leptin actions.Neuroscience. 2013 Aug 23;252C:289-301.

• There are now over 1200 obese children being followed and treated in our obe-
Highlights
sity clinic. Genetic/genomic, epigenetic, metabolic, hormonal, and metabolomic

studies are being carried-out with several new genes being identified as possible

causes of their condition. Metabolomic analyses, focusing on identification of
possible markers for suceptability for the development of insulin resistance, are

underway and promising. Funding from the Fondo de Investigación Sanitario

was renewed this year to continue these studies.

• A new addition of the “Clinical practice guide for the prevention and treatment
of childhood obesity”, commisioned by the Ministry of Health, was produced this

past year.

• The identification of a new cause for isolated growth hormone deficiency, which

courses with obesity, was identified and accepted for publication in EMBO Mo-
lecular Medicine. This gene, RNPC3,codes for a a minor spliceosome protein

required for U11/U12 small nuclear ribonucleoprotein formation and splicing of

U12-type introns. This is the first demonstration of a mutation of a protein of
the minor spliceosome resulting in a specific disease.

• Our studies on the role of glial cells in metabolic control have recieved increa-

sing attention during the past year. The involvement of hypothalamic inflam-

mation and gliosis in the production of obesity-related complications has been
an active area of investigation and we have demonstrated that these processes

are directly related to the underlying cause of the weight gain or obesity.

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