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• c o, c D, c Mi, s JV, s i, F-M G .. In vivo
Most relevant astañerorellaoVasorlíuBiranaloresateoet al
transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients:
scientific a randomized controlled trial.Am J Clin Nutr. 2013 Sep;98(3):845-53.

articles
• F M, V rM, F-c s, G M, s r, s i .. Olive oil
arràsallsernánDezastilleJoiraltolàuBiranaet al
polyphenols enhance the expression of cholesterol efflux related genes in vivo in

humans. A randomized controlled trial.J Nutr Biochem. 2013 Jul;24(7):1334-9.

• Martín-Peláez s, coVas Mi, Fitó M, Kušar a, PraVst i. Health effects of olive oil polyphe-
nols: recent advances and possibilities for the use of health claims.Mol Nutr Food

Res. 2013 May;57(5):760-71.

• KonstantiniDou V, coVas Mi, sola r, Fitó M. Up-to date knowledge on the in vivo
transcriptomic effect of the Mediterranean diet in humans.Mol Nutr Food Res. 2013

May;57(5):772-83.

• yuBero-lahoz s, roBleDo P, Farré M, De latorre r. Platelet SERT as a peripheral bio-
marker of serotonergic neurotransmission in the central nervous system.Curr Med

Chem. 2013;20(11):1382-96.

Recently The PREDIMED trial showed that long-term adherence to energy unres-
Highlights
tricted Mediterranean diet supplemented with extra-virgin olive oil or mixed nuts
reduced incident cardiovascular disease in older subjects at high risk (Estruch et

al. NEJM 2013). At present we are involved in the PREDIMED-plus Study, which is

a randomized clinical trial for the primary prevention of cardiovascular disease with
an energy-restricted Mediterranean diet and intensive lifestyle intervention directed

to lose weight in older subjects with overweight or obesity and metabolic syndrome

(FIS 2013- PI13/00233).

In addition the group is working in randomized trials with functional olive oils which
are enriched in bioactive compounds (Plan Nacional 2013- AGL2012-40144-C03-01),

such as the VOHF Study, a randomized trial with 33 volunteers with dyslipidemia.
The volunteers consumed 3 different types of virgin olive oil: one enriched with

phenol compounds derived from olive oil, one enriched with compounds derived

from thyme, and virgin olive oil, used as a control. The study of the bioavailability
and bioactivity of these compounds is also under our scientific scope (Kotronoulas

A et al. Pharmacol Res 2013).

We have described an improvement of the expression of key genes realted to cho-

lesterol efflux after a virgin olive oil intervention (Farràs M et al. J Nutr Biochem
2013; ). Also, the in vivo transcriptomic effect of the Mediterranean diet in humans

has been described in high-cardiovascular risk patients (Castañer O et al. AJCN
2013, Konstantinidou V. Mol Nutr Food Res 2013).

A very new research line focuses on changes in microbiotic intestinal flora produced

by a nutritional intervention has been standardized and developed (Martín-Peláez S 13
0
et al. Mol Nutr Food Res 2013).
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Finally, epigallocatechin-3-gallate, has been described to rescue cognitive deficits PO
in Down syndrome in mouse models and in humans (De la Torre R et al. Mol Nutr E
R
Food Res. 2014).
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