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• A S, M A, g X, F C, F-V M, A B .. Regional gray
Most relevant leMAnyASoldBergAlCónATJóilASriASeT Al
matter reductions are associated with genetic liability for anxiety and depression: an
scientific
MRI twin study.J Affect Disord. 2013 Jul;149(1-3):175-81.
articles
• MiTJAnS M, SerreTTi A, FABBri C, gASTó C, CATAlán r, FAñAnáS l eT Al.. Screening genetic
variability at the CNR1 gene in both major depression etiology and clinical response

to citalopram treatment.Psychopharmacology (Berl). 2013 Jun;227(3):509-19.

• AleMAny S, AriAS B, FATJó-VilAS M, VillA h, MoyA J, iBáñez Mi eT Al.. Psychosis-inducing
effects of cannabis are related to both childhood abuse and COMT genotypes.Acta

Psychiatr Scand. 2013 Feb 28;.

• CórdoVA-PAloMerA A, goldBerg X, AleMAny S, nenAdiC i, gASTó C, FAñAnáS l. Letter to the
Editor: Low birth weight and adult depression: eliciting their association.Psychol

Med. 2013 Nov 11;:1-3.

• AleMAny S, riJSdiJK FV, hAworTh CM, FAñAnáS l, PloMin r. Genetic origin of the rela-

tionship between parental negativity and behavior problems from early childhood
to adolescence: a longitudinal genetically sensitive study.Dev Psychopathol. 2013

May;25(2):487-500.

Highlights
• Reduced gray matter described in different brain regions in relation to depres-
sion and anxiety disorders is associated to genetic factors of vulnerability to

such disorders; this conclusion was obtained in the context of a neuroimaging

study based on monozygotic twins. This allows to distinguish between genetic
and environmental effects on a complex phenotypes of interest in Psychiatry.

• The cannabinoid system and his associated genetic variation explain part of the

vulnerability and response to drug treatment with Citalopram in depression.

• The inductive capacity of psychotic symptomatology associated with the use of

cannabis is not only modulated by genetic variants in the COMT gene but by

early experiences of maltreatment, according to a complex interaction model
GxExE .

• Subtle differences in birth weight may explain part of the risk observed in adult-

hood to suffer anxiety-depressive spectrum disorders; new studies are neces-

sary.

• Behavioral problems in childhood and adolescence are not independent of some
genetic factors related to parental rearing styles.

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