Page 83 - MemoriaSAM-Eng

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• Elucidation of the mechanisms through which stress exposure increases suscep-

tibility and cell damage in the intestine. Identification of potential therapeutic

targets and evaluation of cytoprotective strategies.

• Evaluation of the therapeutic potential of the endocannabinoid system in neu-
ropsychiatric and gastrointestinal pathologies caused by stress.

• Potential new mechanisms: role of innate immunity receptors (TLRs) in stress-
related processes in neuro-psychiatric pathologies models.

• Study of the neuroprotective effects resultant from the administration of differ-

ent types of antidepressant and antipsychotic drugs in animal models (in vivo

and in vitro) of psychiatric diseases.

• gArCíA-Bueno B, Bioque M, MAC-dowell KS, BArConeS MF, MArTínez-CengoTiTABengoA M,
Most relevant P-C l .. Pro-/Anti-inflammatory Dysregulation in Patients With First é
inAAMAChoeT Al
scientific Episode of Psychosis: Toward an Integrative Inflammatory Hypothesis of Schizo-
phrenia.Schizophr Bull. 2013 Mar 13;.
articles

• MACdowell KS, díAz-MArSá M, güeMeS i, rodríguez A, lezA JC, CArrASCo Jl. Inflam-
matory activation and cholinergic anti-inflammatory system in eating disorders.

Brain Behav Immun. 2013 Aug;32:33-9.
í

• Prez-CABAllero l, Pérez-egeA r, roMero-griMAldi C, PuigdeMonT d, MoleT J, CASo Jr eT
.. Early responses to deep brain stimulation in depression are modulated by anti-
Al
inflammatory drugs.Mol Psychiatry. 2013 May 28;.

• Bioque M, gArCA-Bueno B, MACdowell KS, MeSeguer A, SAiz PA, PArellAdA M eT Al.. Peri-
pheral Endocannabinoid System Dysregulation in First-Episode Psychosis.Neuropsy-

chopharmacology. 2013 Jul 4;.
í

• hinoJoSA Ae, CASo Jr, gArCA-Bueno B, lezA JC, MAdrigAl Jl. Dual effects of nora-
drenaline on astroglial production of chemokines and pro-inflammatory mediators.

J Neuroinflammation. 2013 Jul 9;10(1):81.
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Highlights
During the year 2013 our group has published 5 articles in scientific journals,
obtaining a mean Impact Factor of 8.4. The 60% of those articles have been pub-
ó
lished in first decile and the 100% in first quartile journals.

Moreover, the group has obtained funds in competitive calls from public and pri-
vate institutions and foundations. In particular, this group in the year 2013 has í

had 3 projects working from public institutions (FIS and MINECO) and it has been

achieved a new grant from the Ayudas de Proyectos de Investigación en Salud
(ISCIII) in its call of 2013. From a private standpoint, the group has been involved

in 4 different projects funded by private institutions (Mutua Madrileña Foundation
13
and Alicia Koplowitz Foundation).
0
A very important chapter in our group is the academic/scientific training of pre- 2
RT
and postgraduate students. In this vein, during the year 2013 a Doctoral Thesis PO
E
has been completed (obtaining the highest mark) and other three are being su- R
pervised at this time. Besides, there are four postgraduate students realizing their AL
U
Master’s Theses and other undergraduate students being research trainees and NN
A
aiming to obtain their Graduate’s Theses.
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Finally, it is important to mention that our group is part of different Research SA
Consortia, such as the Instituto de Investigacin Hospital 12 de Octubre and the ER
B
Instituto Universitario de Investigacin en Neuroqumica (UCM).
CI

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