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RESEARCH GROUPS
Nucleic Acid Chemistry Group
Programme: Nanomedicine
Lead Researcher: Eritja Casadellà, Ramón Group Members
STAFF MEMBERS: Aviñó Andrés, Ana María | Grijalvo Torrijo, Santiago ASSOCIATED MEMBERS: Fabrega Claveria, Carmen | Pérez Rentero, Sonia | Tintore Gazulla , María CONTRIBUTORS: Alagia, Adele
Main lines of research
• Development of new molecules which bind to DNA . Study of the interaction of drugs with DNA .
• Synthesis of oligonucleotides with non-natural nucleosides .
• Synthesis of modified RNA for the inhibition of gene expression by the RNA interference mechanism .
• Development of novel formulations for gene therapy and gene silencing .
• Synthesis and structural studies of quadruplex-forming oligonucleotides .
• Triple helix-forming oligonucleotides . Application of triplex affinity capture for the analysis of nucleic acid sequences .
• Two-dimensional DNA crystals . Origami DNA .
• Synthesis of oligonucleotide-peptide conjugates .
• Use of oligonucleotides in biosensors . Surface functionalization with nucleic acid derivatives .
• Study of DNA repair processes with the aim of developing inhibitors that can be used to avoid resis- tance to chemotherapy .
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CIBER-BBN » Annual report 2014
