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Most relevant scientific articles
• sePúlVeDa-CresPo D., lorente r., leal M., góMez r., De la Mata F.J., JiMénez J.l. et al . Synergistic acti- vity profile of carbosilane dendrimer G2-STE16 in combination with other dendrimers and antire- trovirals as topical anti-HIV-1 microbicide . Nanomedicine: Nanotechnology, Biology, and Medicine . 2014;10(3):609-618 .
• Perise-Barrios a.J., JiMénez J.l., D’ oMinguez-soto a., De la Mata F.J., CorBi a.l., góMez r. et al . Carbo- silane dendrimers as gene delivery agents for the treatment of HIV infection . Journal of Controlled Release . 2014; 184(1):51-57 .
• VaCas-CórDoBa e., galÁn M., De la Mata F.J., góMez r., Pion M., Munoz-FernÁnDez M.a. Enhanced activity of carbosilane dendrimers against HIV when combined with reverse transcriptase inhibitor drugs: Sear- ching for more potent microbicides . International Journal of Nanomedicine . 2014; 9(1):3591-3600 .
• VaCas-CórDoBa e., CliMent n., De la Mata F.J., Plana M., góMez r., Pion M. et al . Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: Steps toward their clinical evaluation . Nanomedicine . 2014; 9(17):2683-2702 .
• Fuentes-Paniagua e., hernÁnDez-ros J.M., sÁnChez-Milla M., CaMero M.a., Maly M., Perez-serrano J. et al . Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents . RSC Advances . 2014; 4(3):1256-1265 .
Highlights
Institution: Universidad de Alcalá Contact: Facultad de Farmacia . Dep . de Química Inorgánica . Campus Universitario . 28871 Alcalá de Henares . Teléfono: 91 885 4685 · E-mail: rafael .gomez@uah .es Web: https://portal .uah .es/portal/page/portal/grupos_de_investigacion/164/Presentacion/QuienesSomos
The activity of the group during 2014 has been centered in the development of new dendritic nanosystems in two directions: (i) design of improved non-viral vectors for gene therapy in HIV and cancer and (ii) design of HIV antiviral, antibacterial and anticancer agents, funded by european (IRSES), national (CTQ2011-23245 (MINECO)) and regional (Consorcio NANODENMED-CM) projects . The research carried out, focused in the search of a new therapeutic approach towards the HIV treatment based on the combined therapy of anionic dendrimers and retroviral drugs, achieving 100% of inhibition both in CCR5 and CXCR4 strains . In addition, new cationic dendritic systems have been developed based on the dendronization of soft and hard nanoparticles to carry short nucleic acid (antisense oligonucleotides or siRNA) within different intramural CIBER-BBN projects .
Results of the research have been presented in several conferences, notably in the 4 th Biodendrimers held in Lugano (Switzerland) and published works consisted of 13 publications and 1 book chapter . The group has continued intensifying its activities related to technology transfer applying for a national Spanish patent based on the use in biomedicine of thiol-terminated dendrimers . Also, along with other research group, we have achieved a proof of concept in humanized mice for the use of a topic microbicide against HIV prevention with an efficacy higher than 85% with a high relevance in the media .
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