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NATIONAL PROJECTS
Estudio [email protected]
CIBERDEM PROJECT
http://www.ciberdem.org/estudio_diabetes.php
CIBERDEM GROUPS: Dr . Gemma Rojo, Dr . Rafael Carmena, Dr . Joan Vendrell, Dr . Luis Castaño, Dr . Manuel Serrano Ríos and Dr . Ramon Gomis .
The di@bet .es study is a project organised and managed by CIBERDEM as one of its strategic activities . The field study and the phenotype library, serotype library and DNA library collection was developed in 2008- 2011, more than 30 researches throughout Spain had contributed to its development .
It is the first study conducted in Spain with the aim of studying the epidemiology of type 2 diabetes in the entire national territory and has furthermore allowed knowing the prevalence of others risk factors associated with diabetes such as obesity, arterial hypertension, hyperlipidemias or metabolic syndrome . It has also allowed systematic collection of precise clinical, nutritional, sociological and sanitary habit information, in addition to a serotype library and DNA library deposited in the CIBERDEM Biobank and is available to the scientific community .
The first manuscript with the results of the main objectives was published in January 2012 (Diabetologia (2012) 55:88-93) . Currently, 17 articles have been published based on the transverse study data in the listed journals and at least 6 others are in different editorial states . Derivative projects funded by AES 2011 are starting to yield results .
The di@bet .es study is a collaborative project in which many groups have provided their experience to study the variety of risk factors related to diabetes, making the results available to all other groups to facilitate the study and integration .
The study on the incidence of diabetes in Spain that will be carried out through a coordinated project funded by ISCIII (AES 2014) was designed in 2014:
• Sub-Project 1 PI14/00710, PI: Gemma Rojo Martínez: Incidence of type 2 diabetes in the di@ bet .es study: the role of fatty acids and VEGFB-regulated transport system in the development of metabolic disorders .
• Sub-Project 2 PI14/01104, PI: Luis Castaño González: Incidence of type 2 diabetes in Spain (Northern Spain: Basque Country and Navarre) . Prevalence of monogenic diabetes in Spain, characteristics and clinical diagnosis .
• Sub-Project 3 PI14/00970, PI: Elías Delgado Álvarez: Determination of epigenetic markers associated with the development of type 2 diabetes mellitus in the Spanish population
• Sub-Project 4 PI14/00874, PI: Felipe Javier Chaves Martínez (Carmena Group): Identification of sequence variations and methylation-hydroxymethylation in the exome associated with the development of type 2 diabetes .
• Sub-Project 5 PI14/00465, PI: Matilde Rodríguez Chacón (Vendrell Group): Identification and characterisation of sTWEAK-regulated microRNas in the adipocyte and the role thereof in insulin resistance-associated inflammatory response . Analysis of its usefulness as biomarkers in the Pizarra and di@bet .es studies .
The di@bet .es study also intervenes in the integrated Project PIE14/00031 whose CIBER coordinator is JM Mato: Understanding obesity (Ob), metabolic syndrome (MetS), type 2 diabetes (T2DM) and fatty liver disease (FL): a multidisciplinary approach . Three CIBERDEM groups participating in this project (G Rojo, R Carmena and R Gomís) .
28 CIBERDEM » Annual report 2014