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CB06/04/0007
Hospital Valle de Hebrón, Barcelona
Juan Genescá
Ascites/renal function /Liver failure Hepatic encephalopathy
CB06/04/0030
Hospital San Pablo, Barcelona
Carlos Guarner
Portal hypertension Ascites/renal function Infection/Translocation
CB06/04/0033
Hospital Germans Trías, Badalona
Ramón Planas
Portal hypertension Ascites/renal function Infection/Translocation Hepatic encephalopathy
CB06/04/0041
Hospital General Universitario, Alicante .
José Such
Ascites/renal function Infection/Translocation
Objectives
• Etiopathogenesis of the renal failure in cirrhosis: therapeutic targets . • Relevance of the intestine in liver damage and systemic inflammation in cirrhosis and its therapeutic
modulation . • Prevention of decompensation in cirrhosis: research for new treatment options . • Molecular targets of dysfunction of hepatic microcirculation in cirrhosis .
Ongoing cooperative clinical projects in 2014
• Multicentre, randomised, double-blind, placebo-controlled study on the efficacy of beta-blockers to prevent decompensation of cirrhosis with portal hypertension . Instituto de Salud Carlos III Clinical Research Project EC08/00122 . Code: PREDESCI . Year started: 2008 . Hospital/participating institutions: H . Santa Cruz y San Pablo, H . Clinic, H . Trias Pujol, H . Valle de Hebron, H . Ramon y Cajal-Universidad de Alcalá, H . Gregorio Marañón, H . Puerta de Hierro Majadahonda, H . Arnau de Vilanova . Principal Investigator/Coordinator: Candido Villanueva, Hospital Santa Creu i Sant Pau, Barcelona .
• Efficacy of albumin and midodrine in the prevention of the complications of cirrhosis in cirrhotic patients in the transplantation waiting list: a double-blind, randomised, controlled study . Code: MACHT study . Year started: 2009 . Hospital/participating institutions: H . Clinic, H . Valle de Hebrón . Principal Investigator/Coordinator: Pere Ginés, Hospital Clinic, Barcelona .
• Treatment of hepatorenal syndrome with terlipressin administered as continuous intravenous infusion with doses adjusted according to hemodynamic response . Code: AMELIORATE study . Year started: 2012 . Hospital/participating institutions: H . Clinic, H . Valle de Hebrón, H . del Mar, H . Sant Pau, H . Germans Trias i Pujol, H . Moises Broggi, H . Parc Taulí . Principal Investigator/ Coordinator: Pere Ginès, Hospital Clinic, Barcelona .
• Treatment of hepatorenal syndrome associated with bacterial infections with terlipressin and albumin . Year started: 2012 . Hospital/participating institutions: H . Clinic, H . Sant Pau . Principal Investigator/Coordinator: Pere Ginès, Hospital Clinic, Barcelona .
• Effects of the beta-adrenergic blocking on heart function, systemic and splanchnic hemodynamics and renal function in cirrhosis patients with refractory ascites . Code ALB-BET . Participating institutions: H . Ramón y Cajal, H . GregorioMarañón . Principal Investigator/Coordinator: Agustín Albillos, Hospital Ramón y Cajal, Madrid .
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