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Most relevant scientific articles
• roDríGuez-lópez r, reyes-palomares a, sáncHez-Jiménez F, meDina m. PhenUMA: a tool for integrating the bio- medical relationships among genes and diseases . BMC Bioinformatics . 2014; 15(1): 375 . PMID: 25420641 .
• perKins Jr, ayuso p, corneJo-García Ja, ranea Ja . The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective . Curr Opin Allergy Clin Immunol . 2014; 14(4): 301-6 . PMID: 24905771 .
• castro-oropeza r, pino-ánGeles a, KHomutoV ma, urDiales Jl, moya-García aa, Vepsäläinen J, persson l, sarabia F, KHomutoV a, sáncHez-Jiménez F. Aminooxy analog of histamine is an efficient inhibitor of mammalian L- histidine decarboxylase: combined in silico and experimental evidence . Amino Acids . 2014; 46(3): 621-31 . PMID: 24129980 .
• sáncHez-Jiménez F, reyes-palomares a, moya-García aa, ranea Ja, meDina má. Biocomputational resources useful for drug discovery against compartmentalized targets . Curr Pharm Des . 2014; 20(2): 293-300 . PMID: 23701544 .
• García-caballero m, cañeDo l, FernánDez-meDarDe a, meDina má, quesaDa ar. The marine fungal metabolite, AD0157, inhibits angiogenesis by targeting the Akt signaling pathway . Mar Drugs . 2014; 12(1): 279-99 . PMID: 24441613
Highlights
Institution: Universidad de Málaga Contact: Facultad de Ciencias . Campus de Teatinos, s/n . 29071 Málaga . Phone: (+349 95 213 16 74 · E .mail: kika@uma .es · Website: www .bmbq .uma .es/procel
In 2014, the unit 741 has accomplished a first phase of PhenUMA development (www .phenuma .uma .es; Rodríguez-López et al ., 2014) . We continue implementing the tool with genetic variant and metabolic data . We have established partnerships with various CIBERER groups (and others, eg . Perkins et al, 2014) . They are giving promising results (unpublished results) . The PhenUMA developers (CIBERER staff members) were awarded with the Malaga Young 2014 prize (Junta de Andalucia) .
The group also maintains experimental activity in the field of biogenic amines . These biomolecules are involved in many low prevalence diseases (rare tumors, idiopathic inflammations, neuropathology, etc) . We have published on the adverse effects of overproduction of histamine and we have found a new family of compounds with pharmacological potential as modulators of the histamine production (Castro-Oropeza et al ., 2014) . In some of the recent reviews published by the group, we express our perspective on advances in biogenic amine systems biomedicine (eg . Sánchez-Jiménez et al, 2014) .
A part of our unit works in angiogenesis drug development, with translational potential for many rare diseases . We located a couple of promising compounds (eg . García-Caballero et al, 2014 .) .
Within the CIBERER framework, we have participated in various training events and promotion of in silico technology (molecular modeling and dynamics) for the development of pharmacological chaperones, as we were taking part in the development of pharmacological chaperones against Gaucher disease .
The CIBERER staff member Armando Reyes-Palomares defended his doctoral thesis with European mention and the highest qualification .
We consider that our group is perfectly into CIBERER . As our activity has essentially a holistic nature, it can work synergistically with other basic and clinical CIBERER groups .
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