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Most relevant scientific articles
• rueDa cb, traba J, amiGo i, llorente-FolcH i, González-sáncHez p, parDo b, esteban Ja, Del arco a, satrús- teGui J . Mitochondrial ATP-Mg/Pi Carrier SCaMC-3/Slc25a23 Counteracts PARP-1-Dependent Fall in Mitochondrial ATP Caused by Excitotoxic Insults in Neurons . J Neurosci . 2015 35(8):3566-81 .
• linDsay KJ, Du J, sloat sr, contreras l, linton JD, turner sJ, saDileK m, satrústeGui J, Hurley Jb . Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina . Proc Natl Acad Sci U S A . 2014 111(43):15579-84 .
• rueDa cb, llorente-FolcH i, amiGo i, contreras l, González-sáncHez p, martínez-Valero p, Juaristi i, parDo b, Del arco a, satrústeGui J. Ca(2+) regulation of mitochondrial function in neurons . Biochim Biophys Acta . 2014 1837(10):1617-24 .
• cascón a, comino-ménDez i, currás-Freixes m, De cubas aa, contreras l, ricHter s, peitzscH m, manciKoVa V, inGlaDa-pérez l, pérez-barrios a, calatayuD m, azriel s, Villar-Vicente r, aller J, setién F, moran s, Garcia JF, río-macHín a, letón r, Gómez-Graña á, apellániz-ruiz m, roncaDor G, esteller m, roDríGuez-antona c, satrústeGui J, eisenHoFer G, urioste m, robleDo m . Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene . J Natl Cancer Inst . 2015 107(5) .
Highlights
Institution: Universidad Autónoma de Madrid Contact: Centro de Biologia Molecular Severo Ochoa Nicolás Cabrera, 1 Campus de Cantoblanco UAM 28049 MADRID · Phone: (+34) 91 196 46 21 · E .mail: jsatrustegui@cbm .csic .es
Our goal is calcium signaling to mitochondria and their involvement in human pathology, focused on the study of mitochondrial signaling systems that do not require entry into the organelle; the mitochondrial carriers of aspartate/glutamate (AGCs) and ATP-Mg/Pi (SCaMCs) . We found that in neurons the Ca2+-dependent mitochondrial carrier of ATP-Mg/Pi, SCaMC-3, is involved in the response to intense stimulations intervening in the acute response to glutamate, during which performs the transport of ATP or ADP in mitochondria . The transport of nucleotides into mitochondria counteracts the nucleotide depletion caused by PARP1 activity and avoids its loss preventing the PTP opening and confers protection against neuronal excitotoxicity in vitro and against seizures induced by kainate in vivo . For these studies we have an intramural project of the CIBERER 14-11 call for the study of the involvement of the permeability transition pore (PTP) in models of diseases affecting the mitochondria for a possible diagnostic and therapeutic use .
Furthermore, progress has been achieved in understanding the glutamate-glutamine cycle and the role of the carrier Aralar/AGC1 in the synthesis of aspartate as neuronal precursor of glial glutamine and glutamate moving our study to the retina . There it has been demonstrated the function of aspartate generated in photoreceptors for glutamate-glutamine synthesis in Müller glia, showing a symbiotic relationship between the two cell types that will help in the understanding of retinal metabolism . Recently our group has joined to the Instituto de Investigación Sanitaria de la Fundación Jiménez (IIS- FJD) which has been granted a UAM-IIS-FJD intramural collaborative project to study the involvement of Aralar/AGC1 in the glutamate-glutamine cycle and in epilepsy .
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