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Most relevant scientific articles
• Villa-morales m, cobos ma, Gonzalez-GuGel e, alVarez-iGlesias V, martinez b, piris ma et al . FAS system deregulation in T-cell lymphoblastic lymphoma . Cell Death Dis 2014; 5: e1110 .
• Vaquero-lorenzo c, lopez-castroman J, bermuDo-soriano cr, saiz-ruiz J, FernanDez-piqueras J & baca-Garcia e . Putative association between the -1415 T/C polymorphism of spermidine/spermine N1-acetyltrans- ferase (SSAT1) gene and alcohol use disorders in women and men . Am J Drug Alcohol Abuse 2014; 40: 240-243 .
• pérez-Gómez e, anDraDa c, caFFarel mm, blasco-benito s, García-taboaDa e, Villa-morales m et al . Canna- binoid receptor CB2 is a pivotal regulator of HER2 oncogenic signaling in breast cáncer . J Natl Cancer Inst 2015 .
• roncero am, lópez-nieVa p, cobos-FernánDez ma, Villa-morales m, González-sáncHez l, lópez-lorenzo Jl et al . Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development . Leukemia 2015 .
• lópez-nieVa p, malaVé m, González-sáncHez l, FernánDez-piqueras J, FernánDez-naVarro p & HernanDez. JS . Phosphorylation of Trp53 at serine 389 plays a key role in the radioadaptive response in mouse thy- mocytes . Mutation Research 2015 .
Highlights
The most remarkable major achievements were focused on the deregulation of FAS/FASL pathway and in the contribution of JAK2 mutations to T-LBL development . Specifically, we have demonstrated that the FAS-FASL system is impaired in a significant fraction of lymphomas through inactivating mutations and/or deregulation of FAS and/or other members of the pathway rendering T-LBL tumour cells more resistant to apoptotic cell death . Regarding JAK2 we have identified one activating TEL- JAK2 translocation and six missense mutations, identifying intra-tumour heterogeneity (subclonal heterogeneity) with implications for targeted therapies and accurately diagnosis . Functional approaches revealed that several JAK2 mutations may activate JAK-STAT signalling pathway and to induce the expression of the potent oncogene LMO2 . Aberrant hypermethylation of SOCS3 also contributes to enhance activation of JAK-STAT signalling in these tumours . We therefore proposed that the use of pan-JAK inhibitors in combination with epigenetic drugs should be considered in future treatments . In addition our team has collaborated in the demonstration that the cannabinoid receptor CB2 is a pivotal regulator of HER2 oncogenic signalling in breast cancer; and in the identification of new susceptibility genes involved in alcohol use disorders .
With regard to projects, our team has participated in a European initiative (OPERRA-604984) (2014- 16) and in an ACCI-CIBERER-12-03 project; and directed several projects: (1) from the Spanish Nuclear Security Council; (2) the Spanish National Plan (SAF2012-36566); (3) and from the IIS-FJD .
Additional results were a doctoral thesis, our participation in one training course, and in several Masters and Post-graduates degrees at several Universities or Institutions (UAM, UCM, CNIO etc .) . Members employed by the CIBERER have participated in multiple training courses organized by the CIBERER itself or other Institutions from the del SNS . Finally, as a member of the IIS-FJD, our team have performed genetic and epigenetic analyses of all T-LBL samples attended in the FJD Hospital .
Institution: Universidad Autónoma de Madrid Contact: Centro de Biología Molecular “Severo Ochoa” · C/ Nicolás Cabrera 1, lab . 327 . 28049 Madrid Teléfonos: (+34) 91 196 46 27 - 91 196 46 53 · E .mail: jfpiqueras@cbm .csic .es
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