Page 58 - MEMOCiberer014-ENG

• evaluation and histopathological diagnosis in preclinical assays of new therapies for primary hyperoxaluria (see section on projects) .
• various neurobehavioral phenotyping studies in murine models: - for type C Niemann-Pick disease, for the laboratory of Dr . Daniel Grinberg-U730 - knockout mouse models for the PPARα, abcd1 and abcd2 genes (KO abcd1, KO PPARα), - double KO abcd1abcd2, triple KO abcd1abcd2PPARα) - a knockout mouse model for the SIRT2 gene (KO SIRT2) - William Beurens model for the Dr . Luis Perez-Jurado and Dr . Victoria Campuzano both of U735
• functional assays of platelets from patients with hemorrhagic syndromes for analyzing the role of endoglin in the platelet-endothelium interaction for Dr . Carmelo Bernabéu’s group-U707
• trials performed for several IDIBELL researchers (not CIBERER) in murine models of RDs: - model of X-adrenoleukodystrophy (double knockout mice for the Abcd1 and Abcd2 genes)
- mice model for Rett Syndrome, in collaboration with Dr . Manel Esteller of the Cancer Epigenetics and Biology Program (PEBC)
- mdx dystrophic mice for the study of the invasive and metastatic phenotype of tumours, in collaboration with Dr . Roser López-Alemany .
OBJECTIVE 2.- TO IMPROVE COMMUNICATION AND COORDINATION BETWEEN SEFALER UNITS.
SEFALer units maintain communication through the service’s web page and email, [email protected], which includes information about its activity, acting like a networking service . They also hold group mee- tings, taking advantage of the annual CIBERER meetings and SEFALer training courses .
SEFALer units can act in a coordinated manner to share animals and perform complete phenotyping on the animal model .
OBJECTIVE 3 TO IMPROVE RELATIONS WITH OTHER CIBER OR RETICS GROUPS
In 2014 relations were maintained with research support groups and services that are outside CIBERER, belonging to other CIBERS or RETICS and performing phenotyping activities on animal models for the mid- term establishment of a national animal model phenotyping network, particularly for rare diseases . The biggest upcoming challenge will be to integrate new nodes in the new CIBER structure that this CIBERER is a part of .
OBJECTIVE 4.- TO IMPROVE EXPOSURE OF SEFALER ACTIVITY.
The SEFALer web page was kept updated in 2014 with monthly notifications and information useful for CIBERER researchers . Relevant service activity has also been included in the “highlighted information” section on the CIBERER portal (publications, organisation of training courses, participation in events, etc .) . It can be asserted that the knowledge possessed by CIBERER units about the SEFALer activity and offer has considerably increased this year . Proof of this is the increase in applications for trials by CIBERER researchers .
In addition, continuous presence in different scientific forums and associations relating to animal experiments, animal models, biomedical research, research on rare diseases, etc ., was maintained .
Part of the result of this exposure of the platform and the new relations created by SEFALer units with other research groups and centres, and obviously on the basis of experience and high scientific quality of the researchers, the involvement of SEFALer in important research projects, in international networks and in national and international preclinical and clinical trials is increasingly more well-known . The following can be highlighted from 2014:
58 CIBERER » Annual report 2014