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Most relevant scientific articles
• BeLoNcLe F., LoreNte J.a., eSteBaN a., Brochard L. . Update in acute lung injury and mechanical ventilation 2013 . American Journal of Respiratory and Critical Care Medicine . 2014;189(10):1187-1193 .
• BroWN a.o., MaNN B., Gao G., haNkINS J.S., huMaNN J., GIardINa J. et al . Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function . PLoS Pathogens . 2014;10(9) .
• IzquIerdo-GarcIa J.L., Naz S., NIN N., roJaS Y., erazo M., MartINez-caro L. et al . A metabolomic approach to the pathogenesis of ventilator-induced lung injury . Anesthesiology . 2014;120(3):694-702 .
• FrutoS-VIVar F., eSteBaN a. . Our paper 20 years later: how has withdrawal from mechanical ventilation changed? . Intensive Care Medicine . 2014;40(10):1449-1459 .
• chacoN-caBrera a., roJaS Y., MartINez-caro L., VILa-uBach M., NIN N., FerrueLo a. et al . Influence of me- chanical ventilation and sepsis on redox balance in diaphragm, myocardium, limb muscles, and lungs . Translational Research . 2014;164(6):477-495 .
Highlights
Institution: Servicio Madrileño de Salud Contact: Hospital Univ . de Getafe · Ctra . Toledo km . 12,5 . 28905 Getafe, Madrid . Phone: (+34) 91 683 49 82 · E .mail: aesteban@ucigetafe .com · Web: www .ciberes .org
• We have implemented a procedure to collect fresh lung tissue from deceased patients . This is a com- plex action as it implies the presence of the investigators at the autopsy to collect fresh tissue for storage at -80o . We already have 40 cases . This tissue is available for genetic studies, and will allow the definition of the genetic phenotype of DAD .
• We have identified by massive sequencing (NGS) a miRNA (miRNA 27a-5p) as a biomarker of DAD in an animal model . We are currently studying the effects of its interference in various models (cells undergoing stretch, ex vivo lung ventilation, in vivo model of VILI) (PI 12/2898) .
• The role of Fas ligand and the subsequent activation of the inflammation and the apoptosis pathways in alveolocapillary permeability and edema formation is being investigated . Also, the role of Fs ligand in the integrity of intercellular tight junctions, and the relationship with alveolocapillary hyperper- meability is under current investigation (PI 12/02451) .
• We have participated as part of the Steering Committee in the to date largest epidemiological study on acute respiratory failure (Lung Safe Study) . The study recruited 31000 patients from all over the world under the auspices of the ESICM .
• We have reported in an animal model for the first time the metabolomic pattern that characterizes Acute Lung Injury . Also, in patients with ARDS due to H1N1 influenza virus we have reported the characteristic metabolomic pattern by NMR (PI 11/02791) (Anesthesiology 2014;120(3):694-702) .
• In a pioneer study, we have reported the myocardial lesions in patients with pneumococcal sepsis that may explain arrhythmias and heart failure under these conditions . This was carried out by the autopsy tissue samples from our group in collaboration with the University of Texas (PloS Pathog . 2014 Sep 18;10(9) .
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