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• Incidence and characterization of S. pyogenes strains causing non-invasive disease: otitis, pharyngitis, and other skin and soft tissue infections .
• S. pyogenes pneumonia. Clinical and epidemiological aspects.
• Phenotypic and genotypic characterization of S. pyogenes isolates.
• Study of antibiotic susceptibility. S. pyogenes mechanisms of resistance to macrolides, tetracyclines and fluoroquinolones .
RESPIRATORY INFECTION CAUSED BY VIRUS .
• Influenza-virus infections. Genetic characterizations of seasonal strains.
• Microbiological characterization of emerging respiratory viruses: influenza pandemic H1N1 and H3N2 virus, human metapneumovirus, bocavirus . Diagnosis and epidemiology of their infections .
• Epidemiology of non- influenza viruses causing ILI. Seasonality, hospitalization and incidence distributed by age groups .
• Value or significance of viral infections in exacerbations of COPD.
• Characteristics of mixed infections by two or more respiratory virus and between viruses and bacteria in pneumonia .
Most relevant scientific articles
• taMaYo e., MoNteS M., GarcIa-areNzaNa J.M., perez-traLLero e . . Streptococcus pyogenes emm-types in northern Spain; population dynamics over a 7-year period . Journal of Infection . 2014;68(1):50-57 .
• FerNaNdez-reYeS M., VIceNte d., GoMarIz M., eSNaL o., LaNda J., oNate e. et al . High rate of fecal carriage of extended-spectrum-ß-lactamase-producing Escherichia coli in healthy children in Gipuzkoa, northern Spain . Antimicrobial Agents and Chemotherapy . 2014;58(3):1822-1824 .
• MoNteS M., taMaYo e., MoJIca c., GarcIa-areNzaNa J.M., eSNaL o., perez-traLLero e. . What causes decrea- sed erythromycin resistance in Streptococcus pyogenes? Dynamics of four clones in a southern Eu- ropean region from 2005 to 2012 . Journal of Antimicrobial Chemotherapy . 2014;69(6):1474-1482 .
• MarhueNda c., BarceLo c., FueNteS I., GuILLeN G., caNo I., Lopez M. et al . Urokinase versus VATS for treatment of empyema: A randomized multicenter clinical trial . Pediatrics . 2014;134(5):e1301-e1307 .
• perez-traLLero e., eSNaL o., MarIMoN J.M. . Progressive decrease in the potential usefulness of meningo- coccal serogroup B vaccine (4CMenB, Bexsero®) in Gipuzkoa, Northern Spain . PLoS ONE . 2014;9(12) .
Highlights
Institution: Asociación Instituto Biodonostia Contact: Hospital Donostia · Po Dr . Beguiristain, s/n . 20080 San Sebastián, Guipúzcoa Phone: (+34) 94 300 71 53 · E .mail: mikcrobiol@terra .com
The group has also participated during 2014 in two research projects related to industry:
• “Strategic research and technological development in biomedical applications nanoglicotecnology and mass spectrometry surfaces for clinical diagnosis and food security .” within the program of stra- tegic research projects of the Department of Economic Development and Competitiveness of the Bas- que Government . This project is coordinated by the CIC biomaGUNE of San Sebastián and achieved competitive funding in 2014 and 2015 in the Etortek call .
• “Easy-PCR lab: preindustrial development of new clinical diagnostic applications as a platform to launch a new business initiative based on easy-PCR technology,” led by Gaiker Foundation , at Zamu- dio Technology Park, Bizkaia . The project objective is to develop a molecular diagnostic kit that can be manufactured at industrial scale with commercial applications in the clinical diagnostics market .
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