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Most relevant scientific articles
• ruIz F.M., SchoLz B.a., BuzaMet e., kopItz J., aNdre S., MeNeNdez M. et al . Natural single amino acid polymorphism (F19Y) in human galectin-8: Detection of structural alterations and increased growth- regulatory activity on tumor cells . FEBS Journal . 2014;281(5):1446-1464 .
• SoLIS d., BoVIN N.V., daVIS a.p., JIMeNez-BarBero J., roMero a., roY r. et al . A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code . Biochimica et Biophysica Acta - General Subjects . 2014 .
• MoScoSo M., eSteBaN-torreS M., MeNeNdez M., GarcIa e. . In vitro bactericidal and bacteriolytic activity of ceragenin CSA-13 against planktonic cultures and biofilms of Streptococcus pneumoniae and other pathogenic streptococci . PLoS ONE . 2014;9(7) .
Highlights
Institution: Agencia Estatal Consejo Superior De Investigaciones Científicas Contact: Inst . de Química Física Rocasolano · C/ Serrano, 119 . Madrid · Phone: (+34) 91 561 94 00 E .mail: mmenendez@iqfr .csic .es
• The antimicrobial activity of ceragenin CSA-13 in planktonic cultures and biofilms of pathogenic strep- tococci, including multidrug-resistant Streptococcus pneumoniae, has been established in collabora- tion with Group 2 of CIBERES (Dr . E . García) (PMID:25006964) .
• We have engineered and characterized a new chimeric lysin (Cpl-711) whose exogenous killing ac- tivity against Strepcotococcus pneumoniae surpasses those of the more potent enzybiotics against this pathogen, in collaboration with Group 2 . Results have been validated in vitro and in vivo (PMID:25733585) .
• A new methodology for generation and validation of bacteria microarrys and their application to the study of epitopes on the pathogen’s surface and interactions with host receptors has been imple- mented using Klebsiella pneumoniae as bacterial model (DOI 10 .1039/C4RA14570d), in cooperation with Group 8 of CIBERES (Dr . V . Regueiro) . The same approach, used also to explore the glycosilation profiles of Haemophilus influenzae no tipable wild-type and several mutants in association with Dr . J . Garmendia (Group 8 of CIBERES), has started to be employed with a large series of pathogens .
• New structure-function relationships have been identified on different lectins of the innate immune system, like galectins 3 and 4, and the macrophage galactose binding lectin (hMGL) . The effect of SNPs on human galectin 8 was also studied .
The activity has generated five publications (two in press), several communications to scientific congres- ses and specialized workshops . The international extension of one patent has been applied for, and there are four doctoral thesis in progress .
PROJECTS
• 2011-2014. Glycomics by High-throughput Integrated Technologies (UE; FP7-HEALTH-2010-260600).
• 2011-2015. Dynamic interactive nanosystems (EU; FP7-ITN-GA:289003).
• 2012-2016.TheSugarCode:from(bio)chemicalconcepttoclinics(UE;FP7-PEOPLE-2012-ITN-317297).
• 2012-2015. Bioinformatics Integrative platform for structure-based drug discovery BIPPED2 (CAM; S2010/BMD-2457) .
• 2013-2015. Exploring exogenous and endogenous factors as tools for the control of infectious and immune processes MINECO; BFU2012-36825) .
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