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2. Treatment
• Comparative effects of different sleep apnea treatments, depending on different characteristics (patient’s personal characteristics, different physiological variables (SaO2), among others) .
• Pre-treatment characteristics of patients and compliance .
• Interventions to improve compliance in different treatments . Role of telemedicine .
• To develop networks to improve management and control of sleep apnea and follow-up (nurses, family, physicians... .)
• Non CPAP treatment of sleep apnea . Aims and objectives
1. Study the management and impact of sleep apnea in the new target populations mentioned above;
2. Develop new technologies to be applied in the diagnosis, treatment and follow up of patients with SAHS,
3. Work on transference protocols as well as a new cost-effective clinical protocols and 4. To start using the Medicine 2 system for working.
Main results until the end of 2014
• Respiratory disorders during sleep have been associated for the first time with an increase in cancer incidence and mortality as well as with higher tumour aggressiveness .
• Refractory arterial hypertension is a growing health issue . The frequency of suffering SAHS in these patients is very high . The diagnosis and treatment of SAHS can significantly reduce blood pressure levels and will require a different clinical approach in managing these patients .
• Apnea models have been developed in completely original animals .
• Ample and validated development with new cost-effective strategies for managing SAHS that have changed clinical practice . These strategies also allow conducting sleep studies in rather uncommon environments (coronary units for example) .
OTHER RESULTS OF THE APNEA CRP:
• Esquinas et Al . (2013) . Rationale and Methodology of the Impact of Continuous Positive Airway Pressure on Patients With ACS and Nonsleepy OSA: The ISAACC Trial . Clinical cardiology, 36(9), OI:10,1002/clc .22166 .
• Almendros I, Monserrat JM, Torres M, et all . Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea . Respir Physiol Neurbiol, 186 (2013) 303– 307 .
• Campos-Rodriguez F, Martinez-García MA, Martinez M, Duran-Cantolla J, de La Peña M, Masdeu MJ, Gonzalez M, del Campo F, Gallego I, Marin JM, Barbe F, MontSerrAt JM, Farre R . Association between Obstructive Sleep Apnea and Cancer Incidence in a large multicenter Spanish Cohort . Am J Respir Crit Med, 2013; 187: 99-105 .
• Almendros I, Wang Y, Becker l, Lennon Fe, ZHeng J, Coats Br, et all . Intermittent hipoxia-induced changes in tumor associated macrophages and tumor malignancy in a murine sleep apnea model . Submitted . Am J Respir Crit Care Med . 2014; 189: 593-601 .
• Isetta V, León C, Torres M et all Telemedicine-based approach for obstructive sleep apnea management: building evidence . Interact J Med Res . 9 de febrero de 2014; 3(1):e6 . doi: 10 .2196/ ijmr .3060 .
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