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Most relevant scientific articles
• StoLz d., koStIkaS k., BLaSI F., BoerSMa W., MILeNkoVIc B., LacoMa a. et al . Adrenomedullin refines mor- tality prediction by the BODE index in COPD: The BODE-A index . European Respiratory Journal . 2014;43(2):397-408 .
• cardoNa p.-J., VILapLaNa c. . Multiple consecutive infections might explain the lack of protection by bcg . PLoS ONE . 2014;9(4) .
• Latorre I., dIaz J., MIaLdea I., Serra-VIdaL M., aLtet N., prat c. et al . IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children . Journal of Infection . 2014 .
• StoLz d., BoerSMa W., BLaSI F., LouIS r., MILeNkoVIc B., koStIkaS k. et al . Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin . Chest . 2014;146(2):328-338 .
• Serra-VIdaL M., Latorre I., FraNkeN k., dIaz J., de Souza-GaLVao M., caSaS I. et al . Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis . Frontiers in Microbiology . 2014;5(SEP) .
Highlights
Institution: Fundación Instituto de Investigación Germans Trias i Pujol Contact: Hospital Universitario Germans Trias i Pujol · Carretera Canyet, 08916 Badalona, Barcelona Phone: (+34) 93 497 88 94 · E .mail: vausina .germanstrias@gencat .cat Webs: http://www .gencat .cat/ics/germanstrias/web_micro/ http://unitatdetuberculosiexperimental .wordpress .com/
Following the WHO priorities stated in the “Global Plan to Stop TB 2006-2015”, over the last few years researchers belonging to group 17 within CIBERES have generated considerable scientific knowledge, with an emphasis on joint publications involving groups form different Programs and collaborations with other national and international groups in the context of the pathogenesis, prevention, diagnosis and treatment of tuberculosis . The researchers of this group have continued investigating new prophylactic and therapeutic vaccines against tuberculosis, and have also developed new experimental animal models that better reproduce infection and disease in humans . Studies have also been carried out that provide new insights into the resistance of M.tuberculosis and multi-drug resistant TB . New procedures have been developed and evaluated for the molecular typing of M.tuberculosis for epidemiological purposes . New immunological techniques to diagnose latent tuberculosis infection have also been evaluated . As a result of this work, the researchers have actively participated in the development of clinical guidelines for the use of new diagnostic tests (interferon-gamma release assays-IGRAs) for latent tuberculosis infection .
Group 17 members have also developed several research projects related to other respiratory pathogens: S.aureus, M.pneumoniae, S.pneumoniae, H.influenzae and respiratory viruses . One line of research in which the group has been active in recent years is the assessment of the importance of the inflammatory response in respiratory tract infections . The main objective is to identify and describe pathogen and host factors that modulate clinical outcome .
Researchers belonging to group 17 are currently involved in five projects funded by the EU in the FP7 framework, and in several research projects funded by national agencies (FIS, Ministry of Economy and others), the industry and the Administration . We have also developed scientific collaboration with other CIBER (CIBER-BBN, CIBERESP, and others) .
The research activities of the group have recently generated six new patents and created a spin-off with the aim of commercializing a new probiotic that may allow treatment shortening in latent tuberculosis infections .
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