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Most relevant scientific articles
• ardaNuY c., de La caMpa a.G., GarcIa e., FeNoLL a., caLataYud L., cerceNado e. et aL. Spread of streptococ- cus pneumoniae serotype 8-st63 multidrug-resistant recombinant clone, Spain . Emerging Infectious Diseases . 2014;20(11):1848-1856 .
• puIG c., doMeNech a., GarMeNdIa J., LaNGereIS J.d., MaYer p., caLataYud L. et aL. Increased biofilm for- mation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections . Applied and Environmental Micro- biology . 2014;80(22):7088-7095 .
• doMeNech a., ardaNuY c., tercero a., GarcIa-SoMoza d., SaNtoS S., LINareS J. . Dynamics of the pneu- mococcal population causing acute exacerbations in COPD patients in a Barcelona hospital (2009- 12): Comparison with 2001-04 and 2005-08 periods . Journal of Antimicrobial Chemotherapy . 2014;69(4):932-939 .
• doMeNech a., ardaNuY c., Grau I., caLataYud L., paLLareS r., FeNoLL a. et aL. Evolution and genetic diversity of the Spain23F-ST81 clone causing adult invasive pneumococcal disease in Barcelona (1990-2012) . Journal of Antimicrobial Chemotherapy . 2014;69(4):924-931 .
• puIG c., MartI S., herMaNS p.W.M., de JoNGe M.I., ardaNuY c., LINareS J. et aL. Incorporation of phosphoryl- choline into the lipooligosaccharide of nontypeable haemophilus influenzae does not correlate with the level of biofilm formation in vitro . Infection and Immunity . 2014;82(4):1591-1599 .
Highlights
Institution: Fundación IDIBELL Contact: Fundación IDIBELL- Hospital Universitario de Bellvitge . Phone: (+34) 93 260 79 30 · E .mail: fina .linares@bellvitgehospital .cat
• The Corporate Research Program on Pneumonia:
PI11/00763 “Multicenter study of adult invasive pneumococcal disease(IPD): epidemiology and mo- lecular characterization of pneumococcal clones in the 13 Valent Conjugate Vaccine era . This study analyze the impact of PCV13 vaccination in the incidence of adult IPD, serotype/genotype distribu- tions and antimicrobial resistance of Streptococcus pneumoniae . The emerging clones and capsular switching were also studied . The mechanisms of resistance to penicillin, macrolides and quinolones and the genetic diversity of neumococcal surface proteins, which are vaccine candidates, were charac- terized . Results . A total of 1558 IPD episodes (949 in the pre-PCV13 period (2008-2009) and 609 in the PCV13 period (2012-2013) . An overall decrease in the incidence of IPD was observed from 12,25 to 7,8/100 .000h, associated with a decrease in the IPD due to PCV13 serotypes and related clones . The serotype 5 was associated with outbreaks of IPD, mainly in the Barcelona area . A new recombi- nant and multiresistent clone of serotype 8 (ST63) was detected . The Sp1992 protein has two alleles, the large one is associated with invasive disease . The decrease in the adult IPD was related with herd protection after PCV13 introduction for children in 2010 . New emerging and recombinant clones and changes in the clonal composition of PCV13 serotypes recommend the future surveillance of IPD . The pneumococcal protein SP1992 could be a good candidate to protein based vaccine due to the asso- ciation with invasive clones . PI11/01106 “Usefulness of a rule based on PIRO model for categorizing hospitalized adults with community-acquired pneumonia” .
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