Page 21 - MEMOCiberobn014-ENG

P4. NEUROCOGNITION AND ENVIRONMENTAL-BIOLOGICAL FACTORS
P4-01. Neurocognition, environmental factors and endocrine-metabolic-genetic factors in extreme weight situations .
GENERAL OBJECTIVE:
Analyze neurocognitive, sensory and neurodevelopmental impairments in extreme body weight situations and interaction thereof with environmental and biological (endocrine-hormonal-genetic) factors .
SPECIFIC OBJECTIVES:
• Examine the neuropsychological (executive and attentional functions), environmental, sensory, psychopathological and neurodevelopmental differences in extreme weight situations (different subtypes of EDs, obesity with and without comorbid ED, when compared with healthy control groups) .
• Identify the differential patterns of change in circulating levels of endocrine-metabolic and genetic factors related to energy balance in ED and obesity, in relation to control groups .
• Examine the interaction between the endocrine-hormonal-genetic functioning (endocannabinoid and hormonal functioning in energy metabolism, among others), cognitive functioning (neurop- sychological performance), sensory functioning (olfactory sensory system), psychopathological functioning (depression and general psychopathology), and exposure to persistent organic com- pounds (environmental hormone disruptors) based on the Body Mass Index (BMI), and determina- tion of endophenotypes associated with BMI variability and the abnormal intake of food .
MILESTONES:
A .1) Expansion and total collection of clinical samples . Comparative analyses of data concerning psychopathological, emotional, neurocognition, environmental and personality aspects in obese patients, related eating disorders and extreme weight situations . BMI-related phenotypic characterization .
A considerable number of cases and controls have been included in order to conduct studies on a powerful sample size . A total of 394 women in extreme weight situations (108 patients with anorexia nervosa, 20 low- weight controls, 119 normal weight controls, 16 overweight controls, 38 obese women with bulimia nervosa/ binging disorder, 51 obese women and 47 morbidly obese women) were included in 2014 .
Several studies in the subprogramme, in which neurocognitive and sensory parameters in extreme weight situations are analysed, have been published or were submitted to be published:
• Villarejo C . et al ., (2014) . Loss of control over eating: a description of the eating disorder/ obesity spectrum in women . Eur Eat Disord Rev . 22(1):25-31
• Baños rM et al ., (2014) . Relationship between eating styles and temperament in an Anorexia Nervosa, Healthy Control, and Morbid Obesity female sample . Appetite . 76; 76-83 doi: 10 .1016/j . appet .2014 .01 .012 .
• Bueno et al ., (2014) . Late Onset Eating Disorders in Spain: Clinical Characteristics and Therapeutic Implications JOURNAL OF CLINICAL PSYCHOLOGY, Vol . 70(1), 1–17
• Granero et al (2014) . Food Addiction in a Spanish Sample of Eating Disorders: DSM-5 Diagnostic Subtype Differentiation and Validation Data . Eur . Eat . Disorders Rev . 22 (2014) 389–396
• Claes et al (2015) . Is Non-suicidal Self-injury Related to Impulsivity in Anorexia Nervosa? Results from Self-report and Performance-based Tasks . Eur . Eat . Disorders Rev . 23 (2015) 28–33
• Fernández-aranda, F . et al . (2015) Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interaction - submitted PLOS ONE .
www .ciberobn .es 21