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Most relevant scientific articles
• arGente j., Flores r., Gutierrez-aruMi a., VerMa B., Martos-Moreno G.a., CusCo i. et al . Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency . EMBO Molecu- lar Medicine . 2014;6(3):299-306 .
• kiM j.G., suyaMa s., koCh M., jin s., arGente-arizón P., arGente j. et al . Leptin signaling in astrocytes re- gulates hypothalamic neuronal circuits and feeding . Nature Neuroscience . 2014;17(7):908-910 .
• Baquedano e., ruiz-lóPez a.M., sustarsiC e.G., herPy j., list e.o., Chowen j.a. et al . The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice . Endocrinology . 2014;155(12):4856-4867 .
• GarCia-CáCeres C., Fuente-Martin e., diaz F., Granado M., arGente- arizón P., FraGo l.M. et al . The op- posing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats . Endocrinology . 2014;155(8):2868-2880 .
• Martos-Moreno G.a., Barrios V., Munoz-CalVo M.t., Pozo j., Chowen j.a., arGente j. Principles and pitfalls in the differential diagnosis and management of childhood obesities . Advances in Nutrition . 2014;5(3):299S-305S .
Highlights
Institution: Servicio Madrileño de Salud Contact: Serv . Endocrinología Hospital Infantil Universitario Niño Jesús · Avda . Menéndez Pelayo, 65 . 28009 Madrid · Tel .: (+34) 91 503 5936 · E .mail: argentefen@terra .com
The funding of the project on childhood obesity (FISPI1302195) began in 2014, with this being a continuation of a previous FIS project . Currently there are 1450 obese children being followed in the clinic and enrolled in these studies . The new aspect of this project is the incorporation of metabolomics to determine what are the early metabolic signs of insulin resistance in these children . The most important results in the past year have been:
1) During this past year we discovered a new monogenic syndrome that affects the GH-IGF1 system causing growth failure, reduced BMI and skeletal abnormalities . This discovery has resulted in new international collaborations .
2) Preliminary metabolomic studies have detected new potential markers for insulin resistance that are actually different between prepubertal males and females . This indicates the importance of analyzing boys and girls seperately even at this early age .
3) The role of glial cells in metabolism have been solidified with the demonstration that the knock-out of the leptin receptor in astrocytes causes a reduction in the anorexic response to this hormone .
4) We have shown that the development of hypothalamic inflammation/gliosis depends on the underlying cause of weight gain and that this may help to explain the different secondary complications associated with different diets .
In 2014 we published the second addition of the Pediatric Endocrinology Handbook, which is widely used throughout Spain and in America .
Two doctoral theses were defended in 2014, with both obtaining the maximum qualification at the Universidad Autónoma de Madrid . We obtained a contract (BFU) for a new doctoral student .
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