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Most relevant scientific articles
• Vázquez C., Botella-Carretero j.i., Corella d., Fiol M., laGe M., lurBe e. et al . White fish reduces cardio- vascular risk factors in patients with metabolic syndrome: The WISH-CARE study, a multicenter rando- mized clinical trial . Nutrition, Metabolism and Cardiovascular Diseases . 2014;24(3):328-335 .
• CanFran-duque a., Pastor o., quintana-Portillo r., lerMa M., de la Pena G., Martin-hidalGo a. et al . Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment . Molecular Nutrition and Food Research . 2014;58(4):687-697 .
• Calderón B., Galdon a., Calanas a., PeroMinGo r., Galindo j., GarCia-Moreno F. et al . Effects of Bariatric Surgery on Male Obesity-Associated Secondary Hypogonadism: Comparison of Laparoscopic Gastric Bypass with Restrictive Procedures . Obesity Surgery . 2014 .
• Vázquez-Castellanos jF, serrano-Villar s, latorre a, artaCho a, Ferrús Ml, Madrid n et al . Altered meta- bolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals .Mucosal immunology . 2014 .
• Vázquez C., arrieta F., Pinera M.j., Balsa j.a., Martínez-Botas j., GóMez-Coronado d. et al . The metaboli- cally unhealthy obese phenotype is mainly associated with hypoadiponectinemia, hyperuricemia and high OPG/RANKL ratio . e-SPEN Journal . 2014 .
Highlights
Institution: Servicio Madrileño de Salud Contact: Hospital Ramón y Cajal Ctra . de Colmenar, km 9 .1 . 28034 Madrid Teléfono: (+34) 91 336 80 77 · E .mail: miguel .a .lasuncion@hrc .es · http://www .ciberobn .es/
During 2014, the group Cholesterol, Nutrition and Obesity (CNO) has contributed along with 10 other groups of the Community of Madrid, to the constitution of ALIBIRD-CM, a consortium that has obtained a grant from the Programa de Actividades de I+D entre grupos, Tecnología 2013 (Comunidad de Madrid, S2013/ABI-2728) with the project proposal entitled “Functional Foods and effective nutritional strategies for the prevention and treatment of chronic diseases” for the following four years . The aim of this multidisciplinary project is to gain the scientific knowledge and technical support for the development of functional foods to aid improving cardiovascular health, reducing obesity and contributing to the prevention and increasing the quality of life of cancer patients . This group will be involved in two of the three major objectives outlined, such as the identification of the cellular and molecular mechanisms of the most characteristic ingredients in the functional foods developed in the context of this project, and in the programmed clinical studies aimed to demonstrate the efficacy of functional foods and nutritional supplements and their use in personalized nutrition of patients with cardiovascular disease, obesity or cancer .
In 2014, this group has also expanded partnerships with other CIBEROBN groups, groups from other CIBER and from abroad, to explore specific issues such as the role of microRNA in lipid metabolism, the relationship between gut microbiota disruption with inflammation, the induction of genomic instability by metabolism alterations and the molecular diagnosis of food allergies . Regarding this last point, members of this group have registered the patent entitled “Method for the prediction of the efficacy of oral immunotherapy for the treatment of allergy to cow’s milk proteins” . Finally, it has been completed the doctoral thesis entitled “Study of the effects of tamoxifen, raloxifene and toremifene on the regulation of cholesterol homeostasis . Impact on reverse cholesterol transport from macrophages” .
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