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Most relevant scientific articles
• Troyano-Rodriguez E ., Llado-Pelfort L ., Santana N ., Teruel-Marti V ., Celada P ., Artigas F . . Phencyclidine inhibits the activity of thalamic reticular gamma-aminobutyric acidergic neurons in rat brain . Biological Psychiatry . 2014;76(12):937-945 .
• Sanchez C ., Asin K .E ., Artigas F . . Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data . Pharmacology and Therapeutics . 2014;:- .
• Jimenez-Sanchez L ., Campa L ., Auberson Y .P ., Adell A . . The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression . Neuropsychopharmacology . 2014;:- .
• Riga M .S ., Soria G ., Tudela R ., Artigas F ., Celada P . . The natural hallucinogen 5-MeO-DMT, compo- nent of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs . International Journal of Neuropsychopharmacology . 2014;:- .
• Mocci G ., Jimenez-Sanchez L ., Adell A ., Cortes R ., Artigas F . . Expression of 5-HT2A receptors in pre- frontal cortex pyramidal neurons projecting to nucleus accumbens . Potential relevance for atypical antipsychotic action . Neuropharmacology . 2014;79:49-58 .
Highlights
The group has led a total of 10 grants during 2014, including 1 EU grant (IMI-NEWMEDS, Grant 115008), 6 Spanish competitive grants (SAF2012-35183, IPT-2012-1208-300000, PI10/01103, PI10/00290, PI12/00156 and RTC-2014-2812-1), 1 international grant (The Brain & Behavior Research Foundation Grant 20003), 1 autonomous community grant (2014SGR798) and 1 contract with a pharmaceutical company . Additionally, two patents have been published on May 1, 2014 (US 2014/0120158 and WO 2014/064258) .
From the studies carried out during 2014, we highlight a) development of novel antidepressant strate- gies using RNAi and deep brain stimulation, b) study of the mechanism of action of novel antidepressant drugs, c) development of preclinical models of schizophrenia, and d) identification of thalamocortical circuits as therapeutic targets in schizophrenia . In particular, we highlight the identification of NMDA receptors in the reticular nucleus of the thalamus as a target for the psychotomimetic actions of phen- cyclidine .
The group activity has resulted in a total of 13 papers (9 original articles, 3 reviews and 1 editorial com- mentary requested by the editor of Biol Psychiatry) . From these, 10 papers are from 1st quartile journals and 8 from 1st decile journals, with 9 national and 4 international collaborations .
Overall, these results keep a solid reputation of the group in the field of Neuropsychopharmacology, as shown by its high level of citations (h-index of PI = 55, with more than 10 .000 citations) . Among the awards and distinctions received during 2014, the PI gave the presidential plenary lecture at the annual congress of the Canadian College of Neuropsychopharmacology (CCNP) in June 2014 (Banff, Canada) .
Institution: Agencia Estatal Consejo Superior De Investigaciones Científicas Contact: Neuroquímica y Neurofarmacología . Inst . de Investigaciones Biomédicas de Barcelona (CSIC) C/ Rossello 161, 6a Pl . 08036, Barcelona · Tel .: (+34) 93 363 23 84 . E-mail: maria .jaramillo@iibb .csic .es · Website: www .iibb .csic .es
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