Page 50 - CIBEREHD-2015-eng

Research Groups
G1081
Programme: Hepatic & Gastrointestinal Oncology Lead Researcher: Bujanda Fernández de Pierola, Luis
Group members
STAFF MEMBERS: Goitia Viaña, Ana Isabel | Labiano Ciriza, Ibone.
ASSOCIATED MEMBERS: Banales Asurmendi, Jesús María | Herreros Villanueva, Marta | Hijona
Muruamendiaraz, Elizabeth | Perugorría Montiel, María Jesús.
Main lines of research
Cancer is the leading cause of death in men and the second in women. Colorectal cancer (CRC) has the largest incidence worldwide and the second in mortality. Our goal is to determine the best test for the early diagnosis of this disease as well as to im- prove its acceptance in screening programs. Other projects include the identification of genetic factors that promote its appearance, response to treatment and the adverse effects of the treatment (EPICO- LON I, II EPICOLON, EPIPOLIP, EPINEO, COLONPREV, SmartHEALTH, EPICOLON III studies). Intestinal metaplasia is a precursor lesion of gastric cancer. Genetic and environmental factors associated with progression are unknown. Identifying these factors will help us to develop more effective prevention pro- grams in these patients. Moreover, we are focused
on the study of new pathogenic mechanisms in or- der to create new treatments and early diagnostic strategies in different gastrointestinal tumors with poor prognosis (i.e., pancreatic cancer, cholangio- carcinoma, hepatocellular carcinoma and gastric cancer). In the hepatobiliary pathophysiology, our aim is to identify the molecular mechanisms in- volved in: the generation and regulation of bile, the pathophysiology of the microvesicles (ie exosomes), the role of the primary cilium of cholangiocytes, as well as the development of various hepatic chronic diseases (ie, chronic liver damage, NAFLD, hemo- chromatosis) and biliary diseases (ie, polycystic liv- er disease, primary sclerosing cholangitis, primary biliary cirrhosis).
50 I Annual report 2015 I CIBEREHD