Page 133 - CIBERER-2015-eng

Most relevant scientific articles
Research Groups
PereZ-gomeZ e, andradas c, Blasco-Benito s, caF- Farel mm, garcía-taBoada e, Villa-morales m, et al. Role of cannabinoid receptor CB2 in HER2 pro-on- cogenic signaling in breast cancer. J Natl Cancer Inst. 2015;107(6):djv077.
Highlights
roncero am, lóPeZ-nieVa P, coBos-FernándeZ ma, Vil- la-moralesm,gonZáleZ-sáncheZl,lóPeZ-lorenZoJl, et al. Contribution of JAK2 mutations to T-cell lympho- blasticlymphomadevelopment.Leukemia.2016;30(1):94- 103.
Our work has made possible the publication of two articles in high impact journals. The most signifi- cant outcomes were: (1) the demonstration of the functional consequences of multiple mutations at the JAK2 gene involved in the development of T-cell lymphoblastic lymphomas, which are able to acti- vate the canonical via (activation of JAK/STAT sig- nalling pathway) and another non-canonical-epige- netic via that operates through the induction of the LMO2 oncogene. These results call for the use of JAK-pan-inhibitors in conventional protocols for the treatment of these diseases (Leukemia; IF. 10,431); and (2) our collaboration to demonstrate that a can- nabinoid receptor plays an important role in the de- velopment of breast cancer (J Natl Cancer Inst; IF: 15,161).
As to investigation projects, it has to be emphasized our involvement in an European project (OPER- RA-604984), the direction of an ACCI-CIBERER-16 (which bring together tree different groups of the CIBERER), our participation in another ACCI project directed by Dr. Rosario Perona, and our continued engagement in the development of a SAF-2012 pro- ject and a Grant-Agreement covered by the IIS-FJD.
It should be also noted that we have presented two doctoral theses, we have organized an advanced training course for science teachers from the Com- munity of Madrid, we have lectured at multiple Spe- cialisation Courses and Masters organized by dif- ferent institutions (UAM, UCM, UAH, CNIO, Escuela de Salud-ISCIII etc., including a Course about the Management in Biomedical Research by the Hos- pital La Paz). Additionally, we have participated in various training courses and meetings organized by the CIBERER and other institutions belonging to the ISCIII, including a joint meeting with the CIBERER, CIBERBBN, the Cluster4eyE, patients associations and OftaRed. Finally, we would like to comment on our work in the Experts Committee on Human Ge- netics (Community of Madrid), and the Chairman- ship of the Scientific Advisory Board of the FARPE/ FUNDALUCE Foundation.
Institution: Universidad Autónoma de Madrid
Contact: Centro de Biología Molecular Severo Ochoa · Nicolás Cabrera, 1 Campus Cantoblanco UAM. 28049 Madrid · Tel.: 91 196 46 53 · E.mail: [email protected]
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