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Research Groups
Group U757
Programme: Inherited Cancer, Haematological & Dermatological Diseases Lead Researcher: Perona Abellón, Rosario
Group members
STAFF MEMBERS: Manguán García, Cristina.
ASSOCIATED MEMBERS: Carrillo García, Jaime | Sánchez Pérez, Isabel | Sastre Garzón, Leandro.
Main lines of research
• Application of a rescue therapy in diseases asso- ciated with telomerase activity deficiency. Signal- ling pathways active in dyskeratosis congenita in response to DNA damage. Improve the activity of nanoparticles and lentiviral vectors for gene ther- apy.
• Development of a therapy base in the GSE24.2 peptide fro the treatment of short telomeres as- sociated diseases, increase oxidative stress and geentic instability.
• Genetic diagnosis of DC y study of telomere leng- ht in patients of DC and idiophatic pulmonary fi- brosis. Study of models of idiopathic pulmonary fibrosis using stem cells and KO mouse models for DUSP1.
• Investigation about the activity of GSE4 for the treatment of idiophatic pulmonary fibrosis.
• UseofGSE4forthetreatmentofataxiatelangiec- tasia.
146 I Annual report 2015 I CIBERER
