Page 154 - CIBERER-2015-eng

Research Groups
Group U761
Programme: Sensorineural Pathology Lead Researcher: Varela Nieto, Isabel
Group members
STAFF MEMBERS: Murillo Cuesta, Silvia | Rodríguez de la Rosa, Lourdes.
AT THE EXPENSE OF THE PROJECT: Jareño Flores, Tania.
ASSOCIATED MEMBERS: Baeza Ochoa de Ocariz, María Luisa | Cediel Algovia, Rafael | Celaya Puértolas, Ad- elaida | Contreras Rodríguez, Julio | García Alcántara, Fernando | Magariños Sánchez, Marta | Rivera Rodríguez, Teresa | Zubeldia Ortuño, José Manuel.
Main lines of research
• Characterization of animal and cellular models of syndromic sensorineural deafness.
- Physiopathology of the deficit and the haplo- insuficiencia in IGF-1 using animal and cellular models. Exploring the role of IGF-1 intracellular networks in hearing loss. Signature neuroinflam- mation and redox balance.
- Interaction genome-environment in animal mod- els of hereditary hearing loss under environmen- tal stress: ototoxic, noise and nutritional deficit.
- Genetic predisposition, cellular senescence and presbycusis.
• Identificationofpotentialtherapeutictargetsand biomarkers for progression of hearing loss.
- Role of regulating the activity of inflammatory kinases p38 MAPKJNK in hearing damage.
•
•
- Role of the loss of function of the RAF (rasopa- thies) family and autophagy genes.
- Participation of micronutrients and the metabo- lism of methionine and homocysteine (hyperho- mocysteinemia).
Testing of new therapies with small molecules and stem cells in animal models of sensorineural deafness.
- Inhibitors of apoptosis.
- Facilitators of cell survival.
- Developers of neuritogenesis.
Animal and cellular models of retinal degenera- tion associated with deficits in IGF-1 and their in- tracellular targets.
154 I Annual report 2015 I CIBERER