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Research Groups
Group U707
Programme: Genetic Medicine
Lead Researcher: Bernabéu, Carmelo
Group members
STAFF MEMBERS: Ruiz Llorente, Lidia.
ASSOCIATED MEMBERS: Botella Cubells, Luisa María | Gallardo Vara, Eunate | Langa Poza, Carmen | Mo-
rales Angulo, Carmelo | Zarrabeitia Puente, Roberto.
Main lines of research
• Studies of expression, function and structure of endoglin and its relevance in hereditary hemor- rhagic telangiectasia and other pathologies such as preeclampsia.
• Genetic and cellular studies on the Spanish popu- lation with hereditary hemorrhagic telangiectasia.
• Molecular diagnostics and characterization of pathogenic mechanisms of hereditary hemor- rhagic telangiectasia in the TGF-beta signaling pathway.
• Cellular and animal models for studying the func- tion of endoglin and ALK1 in physiopathology.
• Newtherapiesforhemangioblastomasandcarci- nomas from the von Hippel Lindau (VHL) disease, produced by constitutive expression of hypoxia inducible factor (HIF).
52 I Annual report 2015 I CIBERER
