Page 57 - CIBERER-2015-eng

Most relevant scientific articles
Research Groups
marcos s., nieto-lóPeZ F., sandonis a., di marco, F., car- doZo m., esteVe, P. and BoVolenta P. Secreted Frizzled Related Proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J. Neurosci. 2015; 35, 4729-4740 (cover caption article)
gómeZ-marín c, tena JJ, acemel rd, lóPeZ-maYorga e naranJo s, de la calle-mustienes e, maeso i, Beccari l, aneas, i, Vielmas e, BoVolenta P., noBrega, m.a, carVaJal
c, BogdanoVic o, doohan r., PuK o, hraBě de angelis m, graW J, gomeZ-sKarmeta Jl, casares F, torres m.*, and BoVolenta P.* Meis1 coordinates a network of genes im- plicated in eye development and microphthalmia. Devel- opment. 2015. 142, 3009-3020.
Beccari l., marco-Ferreres r., taBanera n., souren m., WittBrodt B., conte i, WittBrodt J. and BoVolenta P. A trans-regulatory code for the forebrain expression of Six3.2 in the medaka fish. J. Biol. Chem. 2015. 290, 26927-
JJ, gómeZ-sKarmeta JL Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topológical associating domains borders. Proc. Natl. Acad. Sci. USA. 2015. 112, 7542-7547.
marcos, s. gonZáleZ, m., Beccari, l., carramolino, l., mar- tin-BermeJo mJ, amarie o, mateos-san martín d., torroJa
Highlights
Our group investigates the mechanisms that con- trol the early development of the vertebrate nervous system, mostly focusing on the visual system. We are particularly interested in those aspects that may help pinpointing the causes of congenital malforma- tions or those related to the onset of neurodegen- erative diseases. Besides the publications that have highlighted in this report, during this year we made progress in the study of Cdon, a component of the Shh signaling pathway, defining its likely implica- tions in congenital developmental defects. This ad- vance has been possible thanks to the collaboration with different clinical groups, including the U704. We have also extended our studies on the morphogen- esis of the eye field with a particular focus on the specification of the retinal pigment epithelium. Fur- thermore, we have established collaborations with different neurologists to progress in the study of the involvement of the protein Secreted Frizzled Related
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hernándeZ-BeJarano, m*, gestri g*, sPaWls, l., nie- to-lóPeZ F, PicKer a, tada m, Brand m, BoVolenta P., Wil- son sW, and caVodeassi F. Opposing Shh and Fgf signals initiate nasotemporal patterning of the retina. Develop- ment. 2015. 142, 3933-3942.
Protein 1 (Sfrp1) in Alzheimer’s Disease. For this pro- ject we have obtained, among others, the support of the “Fundacion Tatiana Perez de Guzmán el Bueno”. Our studies have also provided support for a strong implication of Sfrp1 in the inflammatory processes associated to neurodegeneration. In collaboration with the U738 we have advanced in the analysis of the neural phenotype that characterize murine mod- els of Lafora disease, which has led to the defense of a doctoral thesis. Our group is leading a national net- work of ten laboratories studying the development of the nervous system (ReDevNeural), for which we have been granted a MINECO project (BFU2014- 55738-REDT). At the international level and within the ERA-Net Neuron II call, we are leading the project “ImprovVision”, aimed at the study and treatment of congenital defects of the visual system.
Institution: CSIC · Centro de Biología Molecular Severo Ochoa · Contact: Campus Cantoblanco. c/ Nicolás Cabrera. 28049 Madrid · Tel.: 91 196 47 18 office / 91 196 47 18 lab · E.mail: [email protected]
Web: http://web4.cbm.uam.es/joomla-rl/index.php/es/index.php?option=com_content&view=article&id=408
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