Page 77 - CIBERER-2015-eng

Most relevant scientific articles
Research Groups
triunFo s, Parra-saaVedra m, rodrígueZ-sureda V, croVetto F, domingueZ c, gratacós e & Figueras F. Angiogenic Factors and Doppler Evaluation in Normally Growing Fetuses at Routine Third-Trimester Scan: Predic- tion of Subsequent Low Birth Weight. Fetal Diagn. Ther. (2015). doi:10.1159/000440650.
eixarch e, muñoZ-moreno e, Bargallo n, Batalle d & gratacos e. Motor and cortico-striatal-thalamic connec- tivity alterations in intrauterine growth restriction. Am. J. Obstet. Gynecol. (2015). doi: 10.1016/j.ajog.2015.12.028.
simões r V., cruZ-lemini m, Bargalló n, gratacós e & sanZ-cortes m. Brain Metabolite Differences in One-Year- Old Infants Born Small at Term and its Association with
Highlights
Unit 719 combines an interdisciplinary team of clini- cal, basic and technological researchers specialized in Fetal Medicine. Many fetal disorders and preg- nancy complications are classified as rare diseases. Our research aims to (1) pathophysiological mecha- nisms and fetal programming, (2) biochemical and imaging biomarkers, (3) development of therapies.
Some of our major scientific and translational mile- stones achieved in 2015 include:
• Improve the prediction of pregnancy complica- tions: coordination of a study aiming to improve the classification and diagnosis of fetal diseas- es with long-term consequences such as brain damage or effects in the cardiovascular system. We will evaluate not only the use of ultrasound markers and standards but also new biological bi- omarkers (nutritional status, hypoxia, hormones, function / placental and toxic environmental ag- ing), among other parameters.
• Perinatal brain damage biomarkers: use of MR diffusion-tractography and computer analysis of cortical development to characterize the effects of preeclampsia and congenital heart disease.
Neurodevelopmental Outcome. Am. J. Obstet. Gynecol. 213, 210.e1–210.e11 (2015).
cruZ-lemini m, crisPi F, ValenZuela-alcaraZ B, Figuer- as F, sitges m, BiJnens B & gratacós e. Fetal cardiovas- cular remodelling persists at 6 months of life in infants with intrauterine growth restriction. Ultrasound Obstet. Gynecol. (2015). doi:10.1002/uog.15767.
rodrígueZ-lóPeZ m, osorio l, acosta r, Figueras J, cruZ-lemini m, Figueras F, BiJnens B, gratacos e & crisPi F. Influence of breastfeeding and postnatal nutri- tion on cardiovascular remodeling induced by fetal growth restriction. Pediatr. Res. (2015). doi:10.1038/pr.2015.182.
• Fetal Cardiology: coordination of several studies aiming to characterize fetal programming and changes in the cardiovascular system over time (fetal life, childhood, adolescence and adulthood), together with studies in experimental and compu- tational models aiming to revert these changes.
• Clinical calculators that integrate the manage- ment of various rare diseases are available on the web, in addition to all our clinical protocols, most of them on rare diseases.
• Collaboration with Perkin Elmer for the devel- opment of new set of biomarkers for predicting growth restriction and preeclampsia in the third trimester of pregnancy.
• New quantitative image analysis method for pre- dicting neonatal respiratory distress risk. In col- laboration with our spin-off TMB, both the patent and the product (Quantus FML) are in the market since 2014.
Institution: Hospital Clínic de Barcelona · Contact: Instituto de Investigaciones Biomédicas C/. August Pi i Sunyer. Sabino de Arana, 1. 08028 Barcelona
Tel.: 93 227 99 06 / 93 227 56 00 Ext 7254/ 93 489 40 69 · E.mail: [email protected] Website: http://www.ciberer.es/index.php?option=com_wrapper&Itemid=120&lang=spanish
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