Page 57 - CIBERSAM-2015-eng

Research Groups
Most relevant scientific articles
leza J.c., Bueno B., BIoque M., aranGo c., Parellada M., do k. et al. Inflammation in schizophrenia: A question of balance. Neuroscience and Biobehavioral Reviews. 2015;55:612-626.
Martínez-cenGotItaBenGoa M, MacdoWell ks, alBerIch s, díaz FJ, García-Bueno B, rodríGuez-JIMenez r et al. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsy- chotics After 1 Year.Schizophrenia bulletin. 2015.
García-Bueno B., BIoque M., MacdoWell k.s., santaBar- Bara J., Martínez-cenGotItaBenGoa M., Moreno c. et al. Pro-/antiinflammatory dysregulation in early psycho-
Highlights
In 2015 our group published several articles on the inflammatory basis in the pathophysiology of men- tal diseases, focused on the search of biomarkers. Most of these articles were performed using sam- ples from patients obtained from collaborations with several clinical groups, and are focused on the origin and consequences of immune response and inflammation in various diseases, especially on the role of innate immunity in psychosis and de- pression. The intramural project FlammPEP, lead- ed by the PI and coordinated with other 8 groups CIBERSAM published several papers this year and one patent has been presented on a new method to predict antipsychotic response in patients after a first psychotic episode. Also, in our preclinical stud- ies (in vivo, ex vivo and in vitro) we shed some light on the way inflammatory signals enter brain struc- tures and their main intracellular pathways. More- over, the group obtained funds in competitive calls
sis: Results from a 1-year follow-Up study. International Journal of Neuropsychopharmacology. 2015;18(2):1-10.
Ferres-coy a., GaloFre M., PIlar-cuellar F., VIdal r., Paz V., ruIz-Bronchal e. et al. Therapeutic antidepres- sant potential of a conjugated siRNA silencing the seroto- nin transporter after intranasal administration. Molecular Psychiatry. 2015.
sayd a., anton M., alen F., caso J.r., PaVon J., leza J.c. et al. Systemic administration of oleoylethanolamide pro- tects from neuroinflammation and anhedonia induced by LPS in rats. International Journal of Neuropsychopharma- cology. 2015;18(6):1-14.
from public and private institutions and foundations. We received invitations to write some expert reviews on the topic published in high impact journals. As an essential part of our goals, the academic/scien- tific training of pre- and postgraduate students has a special chapter. During 2015 one PhD Thesis has been completed (obtaining the highest score), on the mechanisms explaining the anti-inflammatory effects of antipsychotics. Our group has a very im- portant participation in the Interuniversity Master on Initiation of research in mental health and other offi- cial Masters. Finally, it is important to mention that our group is part of different Research Consortia, such as the Research Institute Hospital 12 de Oc- tubre and the University Institute of Neurochemistry (UCM). Several members have participated in meet- ings with patients and families. Finally, the group co-coordinated a new edition of the Laboratorio de Ideas for young researchers.
Institution: Universidad Complutense de Madrid · Contact: Facultad de Medicina. Pza. Ramón y Cajal, s/n. Ciudad Universitaria. 28040 Madrid · Tel.: 913941478 · E.mail: [email protected]
Web: www.ucm.es/farmacologia/neuropsicofarmacologia-molecular-de-las-patologias-relacionadas-con-el-estres
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