Page 65 - CIBERSAM-2015-eng

Research Groups
Most relevant scientific articles
Martínez-cenGotItaBenGoa M, MacdoWell ks, alBerIch s, díaz FJ, García-Bueno B, rodríGuez-JIMenez r et al. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsy- chotics After 1 Year.Schizophrenia bulletin. 2015.
JIMénez-sánchez l, castañé a, Pérez-caBallero l, GrI- Foll-escoda M, lóPez-GIl x, caMPa l et al. Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cor-
roMero-GrIMaldI c, Berrocoso e, alBa-delGado c, MadrIGal Jl, Pérez-nIeVas BG, leza Jc et al. Stress Increases the Negative Effects of Chronic Pain on Hip- pocampal Neurogenesis.Anesthesia and analgesia. 2015;121(4):1078-88.
duenas M., salazar a., oJeda B., Fernández-PalacIn F., MIco J.a., torres l.M. et al. A nationwide study of chronic pain prevalence in the general spanish population: Iden- tifying clinical subgroups through cluster analysis. Pain
tex.Cerebral cortex (New York, N.Y. : 1991). 2015.
BorGes G.P., MIco J.a., neto F.l., Berrocoso e.. Corti- cotropin-releasing factor mediates pain-induced anxiety through the ERK1/2 signaling cascade in locus coeruleus neurons. International Journal of Neuropsychopharma- cology. 2015;18(8):1-6.
Highlights
Throught 2015 the group has continued along the same lines of research that have previosly been de- veloped. There have been important advances in dif- ferent pathologies that have been published in high impact journals, all of them in collaboration with oth- er groups CIBERSAM or another inernational group. Specifically, in depression we have helped to clarify the molecular mechanisms involved in antidepres- sant treatment response of deep brain stimulation (DBS), involving the AMPA receptors. In schizophre- nia, we have been able to identify risk / protective involved in first psychotic episodes, specifically related to BDNF and TrkB receptors. In the field of anxiety, we have identified the neurobiological caus- es underlying the occurrence of anxiety as a result of suffering chronic pain, with a direct involvement of the locus coeruleus and CRF signaling through ERK1 / 2. We have also been able to establish a de-
Medicine (United States). 2015.
crease in neurogenesis in the hippocampus when chronic stress is present at a situation of experi- mental chronic pain, which can justify the presence of depression and cognitive disorders. Finally, a col- laborative study nationwide, has been able to set the frequency of mental disorders associated with chronic pain in the Spanish population. In 2015, the group has registered two patents in collaboration CIBERSAM with the University of Seville and the Uni- versity of Cádiz, specifically an in vitro method for prognosis and prediction of response to treatment with antipsychotics in first psychotic episodes and a process for obtaining the pharmaceutical composi- tion of polymeric nanoparticles for the treatment of neuropathic pain caused by peripheral nerve com- pression.
Institution: Universidad de Cádiz · Contact: Facultad de Medicina · Calle Ancha, 16. 11001 Cádiz Tel.: +34 95 601 52 47 · E.mail: [email protected]
Web: http://www.neuropsychopharmacology-psychobiology.com
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